血管紧张素转换酶2基因多态性与2型糖尿病合并冠心病遗传易感性的关系

目的 探讨血管紧张素转换酶2(ACE2)基因多态性与2型糖尿病患者及其心血管并发症的关系.方法 选择门诊与住院的汉族无血缘关系的糖尿病患者215例,分为单纯2型糖尿病组(121例)及T2DM合并冠心病组(94例).应用PCR-RFLP方法检测ACE2基因多态性,并结合临床、生化指标及超声心动图参数进行分析.结果 在2型塘尿病合并冠心病组患者中,男性G8790A位点G等位基因室间隔厚度明显高于A等位基因(P＜0.01),左心室质量指数及校正后尿蛋白量均高于A等位基因(P＜0.05).而在糖尿病组及女性糖尿病合并冠心病组中未得出同样结论.结论 ACE2基因G8790A位点多态性与男性2型糖尿病患者合并冠心病的室间隔、左室质量及尿蛋白含量有关.

Relationship of angiotensin-converting enzyme 2 gene polymorphisms and vulnerability to coronary heart disease in patients with type 2 diabetes mellitus

OBJECTIVTo investigate the association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms and coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). METHODS: This study involved 121 patients with T2DM and 94 with diabetic macroangiopathy. The polymophisms of G8790A in ACE2 gene was analyzed using PCR-restriction fragment length polymorphism analysis in these patients, and the clinical, biochemical and echocardiographic data were also analyzed. RESULTS: No obvious difference was found in the genotyping data between the two groups. Among the male patients with diabetic macroangiopathy, the interventricular septal end-diastolic thickness (IVSTd) were significantly greater in patients of GG genotypes of ACE2 gene G8790A than in those of AA genotypes (P<0.01), and the left ventricular mass (LVMI) and urine protein were also significantly higher in GG genotypes (P<0.05). No similar results were found the uncomplicated diabetic group or the female diabetic patients with CAD. CONCLUSION: The ACE2 gene G8790A polymorphism plays a role in the pathogenesis of CAD in patients with type 2 diabetes, suggesting that ACE2 genotyping is helpful to screen the susceptible patients.