首页 | 本学科首页   官方微博 | 高级检索  
     


Subgroup Variations in Bone Mineral Density Response to Zoledronic Acid After Hip Fracture
Authors:Jay S Magaziner  Denise L Orwig  Kenneth W Lyles  Lars Nordsletten  Steven Boonen  Jonathan D Adachi  Chris Recknor  Cathleen S Colón‐Emeric  Peter Mesenbrink  Christina Bucci‐Rechtweg  Guoqin Su  Rasheeda Johnson  Carl F Pieper
Affiliation:1. University of Maryland, Baltimore, MD, USA;2. Duke University Medical Center and the Geriatrics Research Education and Clinical Center, Veterans Affairs Medical Center, Durham, NC, USA;3. Oslo University Hospital, University of Oslo, Oslo, Norway;4. University of Leuven, Leuven, Belgium;5. St. Joseph's Healthcare, McMaster University, Hamilton, ON, Canada;6. United Osteoporosis Centers, Gainesville, GA, USA;7. Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
Abstract:Minimizing post‐fracture bone loss is an important aspect of recovery from hip fracture, and determination of factors that affect bone mineral density (BMD) response to treatment after hip fracture may assist in the development of targeted therapeutic interventions. A post hoc analysis of the HORIZON Recurrent Fracture Trial was done to determine the effect of zoledronic acid (ZOL) on total hip (TH) and femoral neck (FN) BMD in subgroups with low‐trauma hip fracture. A total of 2127 patients were randomized (1:1) to yearly infusions of ZOL 5 mg (n = 1065) or placebo (n = 1062) within 90 days of operation for low‐trauma hip fracture. The 1486 patients with a baseline and at least one post‐baseline BMD assessment at TH or FN (ZOL = 745, placebo = 741) were included in the analyses. Percentage change from baseline in TH and FN BMD was assessed at months 12 and 24 and compared across subgroups of hip fracture patients. Percentage change from baseline in TH and FN BMD at months 12 and 24 was greater (p < 0.05) in ZOL‐treated patients compared with placebo in most subgroups. Treatment‐by‐subgroup interactions (p < 0.05) indicated that a greater effect on BMD was observed for TH BMD at month 12 in females, in patients in the lower tertile body mass index at baseline (≤22.6 kg/m2), and in patients with baseline FN BMD T‐score of ≤ –2.5; for FN BMD in patients who received ZOL for >6 weeks post‐surgery; and for TH and FN BMD in patients with a history of one or more prior fractures. All interactions were limited to the first 12 months after treatment with none observed for the 24‐month comparisons. (Clinical trial registration number NCT00046254.) © 2014 American Society for Bone and Mineral Research.
Keywords:CLINICAL TRIALS  OSTEOPOROSIS  INJURY/FRACTURE HEALING  FRACTURE PREVENTION  ANTIRESORPTIVES
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号