吸毒人群HBV、HCV感染状况及吸毒合并两种病毒感染对ALT异常的影响

目的 :为评估湛江市吸毒人群 HCV、HBV的感染状况 ,以及吸毒合并 HCV、HBV感染对血清 AL T异常的影响。方法 :收集 2 0 0 2 - 0 2～ 2 0 0 3- 0 3湛江市吸毒人群资料 ,并对调查对象进行血清 HCV、HBV和 AL T的检测。结果 :湛江市静脉吸毒人群的 HBs Ag阳性率、HCV感染率和 HBV感染率分别为 2 4 .6 1%、5 7.87%、6 7.32 % ,明显高于对照组(11.0 3%、0 .91%、5 1.96 % ) ,有显著性差异 ,非静脉吸毒组此 3项与对照组比较无显著性差异 ;HBV单项、HCV单项、HBV和 HCV混合项 ,这 3种组合感染的静脉吸毒者 ,他们血清中的 AL T异常率分别为 15 .6 9%、33.33%、4 5 .5 0 % ,这3种 AL T异常率分别与未感染 HBV、HCV的静脉吸毒者的 AL T异常率 (9.84 % )比较 ,前者无显著性差异 ,后两者有显著性差异。结论 :静脉吸毒是吸毒者感染 HBV、HCV的重要途径 ;HCV感染对静脉吸毒者血清 AL T的异常起重要作用

Prevalence of HBV and HCV Infections in Druggers and ALT Alteration Due to Them

Objective:To understand the prevalence of HBV and HCV infections in druggers, and ALT alteration of druggers with HBV or HCV infection.Methods:Druggers in Zhanjiang city were chosen for subjects, whose HCV and HBV infections and ALT alterations were determined.Results:The positive rate of HBsAg and infectious rates of HCV and HBV were24.61%, 57.87% and 67.32% ,respectively, which were much higher than 11.03%,0.91% and 51.96% ,respectively in control group. But no statistical significance was observed between nonintravenous druggers and the control group.For intravenous druggers,abnormal ALT rates were 15.69% in subjects with only HBV infection,33.33% in subjects with only HCV infection and 45.50% in subjects with mixed infections of HBV and HCV. Except the ALT rate of subjects with only HBV infection ,significant differences in ALT rates of subjects with only HCV and with mixed infectionswere found between intravenous druggers and nonintravenous druggers.Conclusion:Intravenous drugtaking was primary way for druggers to be infected with HBV and HCV. HCV infection played an important role in resulting in ALT alteration.