Inhibition of anaphylactic histamine releasein vitro by GABA |
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| Authors: | S. Luzzi S. Franchi-Micheli S. Spagnesi Elisabetta Rosi M. Ciuffi Lucilla Zilletti |
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| Affiliation: | (1) Department of Pharmacology, University of Florence, Viale G. B. Morgagni 65, 50134 Florence, Italy |
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| Abstract: | Inhibitory effect of GABA on anaphylactic histamine releasein vitro is not mimicked by 2-aminoethansulphonic acid (taurine), an aminoacid unrelated to GABA neurotransmission.Tetrodotoxin (TTX) 6×10–7M, a concentration known to block neuronal mechanism but not to modify muscle membrane and anaphylactic histamine release, strongly prevented the inhibition caused by GABA in the Schultz-Dale reaction and in anaphylactic histamine release.The inhibitory effect of GABA on anaphylactic reactionin vitro thus appears to be specific for this aminoacid and is neurogenic in nature, in that it requires integrity of neuronal mechanisms. |
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