| 消炎痛对人胃癌上皮细胞BGC-823的作用 |
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| 引用本文： | 李莲,朱辉,冯桂香,郑先科. 消炎痛对人胃癌上皮细胞BGC-823的作用[J]. 郧阳医学院学报, 2002, 21(6): 333-335 |
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| 作者姓名： | 李莲 朱辉 冯桂香 郑先科 |
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| 作者单位： | [1]郧阳医学院生理学教研室，湖北十堰442000 [2]东风公司总医院麻醉科 |
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| 摘 要： | 目的 :探讨非甾体类抗炎药 (NSAIDs)消炎痛 (indomethacin ,IND)对人胃癌细胞BGC - 82 3的作用 ,以期为非甾体类抗炎药对胃癌的防治作用提供理论依据。方法 :采用DNA条带分析以及流式细胞仪分别从定性及定量的角度观察不同浓度的消炎痛引起的BGC - 82 3细胞凋亡情况 ;MTT法分析不同浓度的消炎痛对BGC - 82 3细胞增殖的影响。结果 :低浓度的消炎痛可引起BGC - 82 3细胞的凋亡并且呈现量效关系 ;MTT分析发现 :消炎痛可抑制BGC - 82 3细胞的增殖 (P <0 .0 5)。结论 :NSAIDs有抑制胃癌细胞增殖、诱导其凋亡的作用 ,提示NSAIDs是一类预防胃肠道肿瘤的可行性药物
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| 关 键 词： | 消炎痛 胃肿瘤 细胞凋亡 增殖 |
| 文章编号： | 1006-9674(2002)06-0333-03 |
| 修稿时间： | 2002-05-24 |
The Effect of Indomethacin on Human Gastric Carcinoma Epithelial Line BGC-823 |
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| LI Lian,ZHENG Xian-ke. The Effect of Indomethacin on Human Gastric Carcinoma Epithelial Line BGC-823[J]. Journal of Yunyang Medical College, 2002, 21(6): 333-335 |
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| Authors: | LI Lian ZHENG Xian-ke |
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| Abstract: | Objective To investigate the effect of indomethacin-a kind of NSAIDs on BGC-823 to indetificate that NSAIDs is valuable drug for prevention of gastroinstential tumor. Methods The apoptosis of BGC-823 was examined by DNA ladder and flow cytometry asssy and the proliferlication of BGC-823 was studied by MTT assay. Results The results of LDH leakage, flow cytometry assay and DNA ladder showed that: IND could induced the apoptosis of BGC-823 in a dose- depend manner. MTT assay showed that the proliferlication of BGC-823 IND was significantly (p<0.05) inhibit by IND.Conclusions The study indicate that NSAIDs could be effective and feasible drug for prevention and therapy of gastroinsteral tumor. |
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| Keywords: | Indomethacin stomach neoplasms apoptosis proliferlication |
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