| 肝达康对DMN致肝损伤大鼠血清透明质酸、Ⅲ型前胶原、层粘连蛋白及肝组织羟脯氨酸水平的影响 |
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| 引用本文： | 柳成刚,王晓丽,姜德友,张硕辛,耿乃志,解颖,乔羽,常佳怡.肝达康对DMN致肝损伤大鼠血清透明质酸、Ⅲ型前胶原、层粘连蛋白及肝组织羟脯氨酸水平的影响[J].中医药学报,2012,40(4):36-38. |
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| 作者姓名： | 柳成刚 王晓丽 姜德友 张硕辛 耿乃志 解颖 乔羽 常佳怡 |
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| 作者单位： | 黑龙江中医药大学,黑龙江哈尔滨,150040 |
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| 基金项目： | 黑龙江省自然科学基金项目（D201037）; 黑龙江省中医药管理局项目（ZHY10-Z4）; 黑龙江省博士后基金资助课题（LBH-Z09010）; 黑龙江中医药大学科研基金资助（200909） |
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| 摘 要： | 目的:观察肝达康对肝损伤大鼠血清透明质酸、Ⅲ型前胶原、层粘连蛋白及肝组织羟脯氨酸水平的影响。方法:55只Wistar大鼠,除空白对照组10只外,其余45只用1%DMN腹腔注射建立肝损伤大鼠模型,并同时分别给予药物或生理盐水灌胃,于第4周末处死全部大鼠,留取血清。观察肝达康对DMN肝损伤模型大鼠血清HA、PCⅢ、LN和肝组织Hyp含量的影响。结果:与正常对照组比,肝损伤模型组大鼠血清HA、PCⅢ、LN和肝组织Hyp含量均明显升高。经肝达康治疗后,上述指标的含量均明显降低。结论:肝达康能降低DMN致肝损伤模型大鼠血清透明质酸、Ш型前胶原、层粘连蛋白及肝组织羟脯氨酸水平。
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| 关 键 词： | 肝达康 肝损伤 透明质酸 Ⅲ型前胶原 层粘连蛋白 羟脯氨酸 |
Effects of GDK on HA, PCIII, LN in Serum of Hepatic Injury Rats Induced by DMN and Its Influence on Content of Hydroxyproline |
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| LIU Cheng-gang
,
WANG Xiao-li
,
JIANG De-you
,
ZHANG Shuo-xin
,
GENG Nai-zhi
,
XIE Ying
,
QIAO Yu
,
CHANG Jia-yi.Effects of GDK on HA, PCIII, LN in Serum of Hepatic Injury Rats Induced by DMN and Its Influence on Content of Hydroxyproline[J].Acta Chinese Medicine and Pharmacology,2012,40(4):36-38. |
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| Authors: | LIU Cheng-gang WANG Xiao-li JIANG De-you ZHANG Shuo-xin GENG Nai-zhi XIE Ying QIAO Yu CHANG Jia-yi |
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| Institution: | LIU Cheng - gang, WANG Xiao - li, JIANG De - you, ZHANG Shuo - xin, GENG Nai - zhi, XIE Ying, QIAO Yu, CHANG Jia - yi (Heilongiiang University of Chinese Medicine ,Harbin 150040, China) |
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| Abstract: | Objective ：To study the influence of GDK on Contents of HA, PCIII, LN and HYP in hepatic injury rats in- duced by DMN. Methods ： Fifty - five Wistar rats excluding ten rats in blank control group, and the other rats were injec- ted DMN to establish hepatic injury model rats. At the same time, all rats were given drugs or distilled water. Blood sam- ples were obtained at the end of the 4th week. The contents of HA, PCIII, LN in serum and HYP in liver were deter- mined. Results：Contents of HA, PCIII, LN in serum and HYP in liver of model rats were increased markedly as com- pared with the blank group. After the therapy of GDK, contents of HA, PCIII, LN and HYP in GDK group decreased. Conclusion ： GDK can decrease the contents of HA, PCIII, LN in serum and HYP in liver of hepatic injury rats Induced by DMN. |
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| Keywords: | GDK Hepatic injury HA PCIII LN HYP |
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