Circulating placental proteins (hCG, SP1 and PP5) in trophoblastic disease |
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| Authors: | J. N. LEE H. T. SALEM T. CHARD S. C. HUANG P. C. OUYANG |
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| Affiliation: | Departments of Obstetrics and Gynaecology, and Reproductive Physiology, St Bartholomew's Hospital Medical College and the London Hospital Medical College, London;Department of Obstetrics and Gynaecology, School of Medicine, National Taiwan University, Taiwan, ROC |
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| Abstract: | Summary. Scrum human chorionic gonadotrophin (hCG), pregnancyspecific β1-glycoprotein (SP1) and placental protein 5 (PP5) levels have been measured by radioimmunoassay in 20 patients (116 samples) with hydatidiform mole, one patient (nine samples) with invasive mole and 10 patients (103 samples) with choriocarcinoma. Measurement of both serum SP1 and hCG are useful in the monitoring of these diseases. The presence of PP5 in hydatidiform mole and its absence in choriocarcinoma support the hypothesis that PP5 is closely associated with the invasive activity of malignant trophoblast. |
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