Aplastic anemia or aplastic preleukemic syndrome? |
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Authors: | T Jameel M Anwar S I A Abdi M Saleem P A Ahmad M F Khattak |
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Institution: | (1) Department of Hematology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan, PK |
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Abstract: | The incidence of aplastic anemia appears to be relatively high in some parts of the world, including Pakistan. Since some
of the etiological factors are shared by aplastic anemia and the preleukemic syndrome, there is a strong possibility that
a proportion of cases of aplastic anemia may in fact be preleukemia.The study of chromosomes offers a relatively easy method
of detecting cases of preleukemia, because some chromosomal abnormalities are frequently observed in this condition. Chromosomal
studies were carried out in peripheral blood cell cultures of 31 patients with otherwise typical aplastic anemia. Chromosomal
abnormalities were detected in 7 (22.5 %) cases. The most common chromosomal abnormality detected was trisomy 8, seen in four
cases. Other abnormalities detected were 22q-, t(14;22) and t(15;21), in one case each. These abnormalities have been found
to be associated with AML, MDS, ALL, and NHL as well. We hypothesize that a proportion of cases of otherwise typical aplastic
anemia may in fact be due to a leukemic process in evolution.
Received: 7 April 1997 / Accepted: 16 June 1997 |
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