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弥漫性甲状腺肿伴甲亢患者的染色体研究
引用本文:孟运莲,张世明,戎诚兴. 弥漫性甲状腺肿伴甲亢患者的染色体研究[J]. 武汉大学学报(医学版), 1986, 0(3)
作者姓名:孟运莲  张世明  戎诚兴
作者单位:河北医学院组织胚胎学教研室,河北医学院组织胚胎学教研室,河北医学院组织胚胎学教研室
摘    要:35名弥漫性甲状腺肿伴甲状腺机能亢进的患者和10名健康人的染色体研究结果表明:(1)患者的染色体结构畸变率显著高于对照组健康人者(P<0.01),结构畸变以单体断裂为主;(2)患者的染色体畸变与性别及硫脲类抗甲亢药物的治疗剂量无关;(3)伴突眼症者和不伴突眼症者之间的染色体结构畸变率有显著性差异,前者高于后者(P<0.05);(4)患者的染色体结构畸变累及多条染色体。

关 键 词:甲状腺机能亢进  染色体畸变

A Study on the Chromosomes of the Patients with Diffuse Goiter Accompanied with Hyperthyroidism
Meng Yunlian,et al. A Study on the Chromosomes of the Patients with Diffuse Goiter Accompanied with Hyperthyroidism[J]. Medical Journal of Wuhan University, 1986, 0(3)
Authors:Meng Yunlian  et al
Abstract:A study of the chromosome of 35 Patients with diffuse goiter accompanied with hyPerthroidism results as follws: 1. The patients' chromosomal aberration rates were much higher than those of the nornal controls (P<0.01). 2. The chromosomal aberration rate of the Patients was not associated with the sex or with the Iherapeutic dose of the antithyroid drugs. 3. The chromosomal aberration rate of the Patients with exophthalmus was higher than that of the patients without exophthalmus (P<0.05). 4. Many chromosomes in the patient suffered structural aberration.
Keywords:hyperthyroidism  chromosome aberrations
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