神经系统副肿瘤综合征34例临床特点分析

目的:分析34例神经系统副肿瘤综合征患者的临床特点。方法:对1990年至2005年收治的34例神经系统副肿瘤综合征患者的临床资料进行回顾性分析。结果:副肿瘤综合征的临床类型有周围神经病15例、Lambert-Eaton肌无力综合征5例、多发性肌炎和皮肌炎3例、进行性小脑变性2例、运动神经元病3例、进行性多灶性白质脑病1例、亚急性坏死性脊髓病1例、脑干脑炎2例、边缘系统脑炎2例。结论:神经系统副肿瘤综合征临床表现形式多样,容易误诊,临床早期确诊对于隐匿肿瘤的发现和治疗非常重要。

Clinical characteristics of 34 cases with paraneoplastic neurological syndrome

Objective: To investigate the clinical characteristics of 34 patients with paraneoplastic neurological syndromes. Methods: we analyzed the clinical data of 34 patients diagnesed as paraneoplastic neurological syndromes from 1990 to 2005 retrospectiveiy.Results: clinical symptoms: peripheral neuropathy was observed in 15 subjects, Lambert-Eaton' s myasthenia syndromes in 5 subjects, poly myositis or dermatomyositis in 3 subjects, progressive cerebellar degeneration in 2 subjects, motor neuron disease in 2 subjects, progressive multifocal leukoencephalopathy in 1 subjects , subacute necrotic myelopathy in 1 subjects, brain-stem encephalitis in 2 subjects , Limbic encephalitis in 2 subjects. Conclusion: The manifestations of PNS were too complicated to be misdiagnostics easily in clinical work, so the early diagnosis is useful to treatment of the underling tumor.