Effect of delayed administration of activated charcoal on nortriptyline absorption |
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Authors: | S Dawling P Crome R Braithwaite |
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Institution: | (1) Poisons Unit, Guy's Hospital, SE1 9RT London, England |
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Abstract: | Summary Activated charcoal is known to reduce the absorption of therapeutic doses of nortriptyline in vivo when administered 30 min after drug ingestion. In a group of volunteers, one sachet (10 g) of a new activated charcoal preparation, Medicoal was found to produce a highly significant reduction in nortriptyline absorption when given as long as four hours after nortriptyline dosing. Activated charchoal may therefore be useful in the treatment of tricyclic antide-pressant poisoning even if a delay of several hours ensues before medical help is sought. |
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Keywords: | Activated charcoal tricyclic antidepressants nortriptyline poisoning antidote man |
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