影响喉癌患者预后的Cox回归分析

目的:探讨影响喉癌患者生存率的相关因素。方法:回顾性分析77例喉癌患者的临床资料,包括年龄、性别、吸烟、族别、肿瘤部位、病理学分级、T分期、N分期、临床分期和治疗方式。应用Kaplan-Meier进行生存分析,组间比较用Log rank检验,多因素分析采用Cox比例风险模型。结果:本组患者总的1年、3年、5年生存率分别为98.7%、73.4%、54.1%。单因素分析提示肿瘤部位、病理学分级、T分期、N分期、临床分期、治疗方式对患者预后的影响均有统计学意义(P<0.05);多因素分析发现肿瘤部位(P<0.05)、病理学分级(P<0.05)、临床分期(P<0.05)、治疗方式(P<0.01)对预后的影响有统计学意义。结论:影响喉癌患者预后的独立因素是肿瘤部位、病理学分级、临床分期和治疗方式。

Multivariate Cox analysis of prognostic factors affecting laryngeal cancer patients

Objective:To investigate the factors affecting the survival rate of laryngeal carcinoma.Methods:Seventy-seven cases were analyzed retrospectively,including sex,age,smoking,race,primary site,pathological grade,T-stage,N-stage,clinical stage,treatment methods.Survival analysis was performed by Kaplan-Meier method;comparison between groups was performed using log rank test;multivariate analysis was carried out using Cox proportional hazard model.Results:Overall 1,3 and 5-year survival rates were 98.7%,73.4% and 54.1% respectively.Univariate analysis showed that primary site,pathological grade,T-stage,N-stage,clinical stage and treatment methods were proven to significant(P<0.05).Multivariate analysis showed the prognosis statistically correlated with primary site(P<0.05),pathological grade(P<0.05),clinical stage(P<0.05) and treatment methods(P<0.01).Conclusion:The independent factors affecting the prognosis of the patients with laryngeal carcinoma are primary site,pathological grade,clinical stage and treatment methods.