经颅多普勒超声动态评价他汀类药物对脑血流影响

目的 通过经颅多普勒超声(TCD)动态评价他汀类药物对缺血性卒中脑血流动力学的影响.方法 通过TCD检查70例首次急性缺血性卒中住院患者的脑血流动力学,根据他们是否规律服用他汀类药物分为服药组和非服药组.发病3个月后再次随访TCD.结果 发现服药组患者发病3个月后双侧大脑中动脉收缩期血流速度、平均血流速度均较发病1周内有上升(P＜0.05).服药组患者发病3个月后双侧大脑中动脉搏动指数较发病1周内有下降(P＜0.05).非服药组患者发病3个月后双侧大脑中动脉血流速度、搏动指数较发病1周内差异无统计学意义(P＞0.05).结论 他汀类药物对改善缺血性卒中脑血流动力学有一定的作用.

The effects of statins on the cerebral haemodynamics measured by transcranial Doppler in ischemic stroke patients

OBJECTIVE: To evaluate the effects of statins on the cerebral haemodynamics of ischemic stroke patients with transcranial Doppler (TCD). METHODS: 70 inpatients with acute ischemic stroke were divided into two groups according whether they had taken statins after stroke. The change of the cerebral haemodynamics was studied in the two groups with TCD three months after stroke. RESULTS: Three months later, the systolic flow velocities and mean flow velocities of bilateral middle cerebral arteries in the statins groups significantly increased (P <0.05). The pulse index of bilateral middle cerebral arteries in statins group significantly decreased (P <0.05). The flow velocities and pulse index of bilateral middle cerebral arteries in control group don't change significantly (P > 0.05). CONCLUSIONS: Statins may have the effects of improving the situation of cerebral haemodynamics of patients with ischemic stroke.