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正交设计筛选抗幽门螺杆菌甲硝唑耐药株天然药物的最佳组合方案
引用本文:胡伟,程丽,王红,周曾芬,李晓燕,段丽萍,陈娅蓉,蒋海燕,贾友兰.正交设计筛选抗幽门螺杆菌甲硝唑耐药株天然药物的最佳组合方案[J].现代消化及介入诊疗,2005,10(4):185-187.
作者姓名:胡伟  程丽  王红  周曾芬  李晓燕  段丽萍  陈娅蓉  蒋海燕  贾友兰
作者单位:650032,昆明医学院第一附属医院消化内科
摘    要:目的筛选天然药物治疗幽门螺杆菌(Hp)甲硝唑耐药株的最佳组合方案。方法运用正交设计方法筛选臭灵丹、石榴皮、蒲公英三种天然药物抗坳甲硝唑耐药株的最佳组合。结果三种天然药物对Hp甲硝唑耐药株的最佳组合方案为:臭灵丹(MIC90,77.9mg/ml),石榴皮(MIC90,131.1mg/ml),蒲公英(MIC75,117.27mg/ml)。结论正交设计方法有效的筛选出了三种天然药物的最佳组合方案.提高了实验效率,节约科研资源。

关 键 词:幽门螺杆菌  甲硝唑  耐药株  臭灵丹  石榴皮  蒲公英  正交设计
收稿时间:2005-10-27
修稿时间:2005年10月27

Screening the best combination of herbs for anti-Helicobacter pylori by Orthogonal Test Method
HU Wei, CHENG Li, WANG Hong,et al..Screening the best combination of herbs for anti-Helicobacter pylori by Orthogonal Test Method[J].Modern Digestion & Intervention,2005,10(4):185-187.
Authors:HU Wei  CHENG Li  WANG Hong  
Institution:HU Wei, CHENG Li, WANG Hong, et al.
Abstract:Objective To find the best combination of Laggera pterodonta, Pomegranate Rind, Taraxacum mongolicum for H.Pylori metronidazole resistant strains. Methods The best combination of Natural Chinese herbs for anti- H.Pylori metronidazole resistant strains was screened by Orthogonal Test Method. Results The best combination scheme of the three Natural Chinese herbs on H.Pylori metronidazole resistant strains was Laggera pterodonta (MIC90, 77.9 mg/ml), Pomegranate Rind (MIC90, 131.1 mg/ml), Taraxacum mongolicum (MIC75,117.27 mg/ml). Conclusion Orthogonal Test Method can enhance the efficiency to screen the best combination of three medical herbs, and is of time saving and resource saving.
Keywords:Helicobacter pylori  Metronidazole  Resistant strains  Laggera pterodonta  Pomegranate Rind  Taraxacum mongolicum  Orthogonal Test Method
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