Changes in the cortical and trabecular bone compartments with different types of menopause measured by peripheral quantitative computed tomography |
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| Institution: | 1. Department of Medicine, Alcalá de Henares University, 28801 Madrid, Spain;2. Department of Obstetrics, Gynecology Service, Principe de Asturias University Hospital, Alcalá de Henares University, 28801 Madrid, Spain;1. Gulhane Research and Training Hospital, Department of Urology, Ankara, Turkey;2. Hacettepe University Faculty of Medicine, Department of Neurology, Ankara, Turkey;3. Kecioren Research and Training Hospital, Department of Urology, Ankara, Turkey;1. Division of Vascular and Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut;2. Birmingham Radiological Group, Birmingham, Alabama;3. American College of Radiology, Reston, Virginia;4. Department of Radiology, Memorial Sloan Kettering Cancer Center, New York City, New York;5. Center for Cancer Research, National Institutes of Health, Bethesda, Maryland;6. Department of Radiology, Stanford Medicine, Palo Alto, California;7. Mass General Imaging, Harvard, Boston, Massachusetts;8. Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Baltimore, Maryland;9. Populational Health Sciences, Weill Cornell Medicine, New York City, New York;10. Digital Health Center of Excellence, Food and Drug Administration, Washington, D.C.;11. Department of Biochemistry and Molecular Medicine, George Washington School of Medicine and Health Sciences, Washington, D.C.;12. Department of Radiology, University of Colorado Anschutz Medical Center, Denver, Colorado;13. Department of Radiology, University of California Irvine, Irvine, California;14. Department of Radiology, Weill Cornell Medicine, New York City, New York;1. Department of Neurosurgery, Yokohama City University, Yokohama, Kanagawa, Japan;2. Department of Neurology, Yokohama Brain and Spine Center, Yokohama, Kanagawa, Japan;1. Prehospital, Resuscitation and Emergency Care Research Unit (PRECRU), Curtin University, Bentley, WA, Australia;2. Intensive Care Unit, Royal Perth Hospital, Perth, WA, Australia;3. St John Western Australia, Belmont, WA, Australia;4. Medical School, University of Western Australia, Crawley, WA, Australia;5. School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia;6. Fiona Stanley Hospital, Murdoch, WA, Australia;7. Sir Charles Gairdner Hospital, Nedlands, WA, Australia;8. Emergency Medicine, Royal Perth Hospital, Perth, WA, Australia;9. Fremantle Hospital, Fremantle, WA, Australia;10. School of Veterinary and Life Sciences, Murdoch University, Perth, WA, Australia;3. Shaoyang University, Hunan, China |
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| Abstract: | Our objective was to study the changes in the bone mineral density of the cortical and trabecular compartments with different types of menopause. A total of 153 normal postmenopausal women (mean age 48 ± 5 years) were studied. The women were divided into three groups based on mean age at menopause: early menopause (menopause before 43 years), normal menopause (menopause at 44–52 years), and late menopause (menopause after 52 years). The number of years since menopause was similar in all three groups (±5 years). Cortical and trabecular bone mineral density was determined in all the women using peripheral quantitative computed tomography. Our results show that only the trabecular bone mineral density differed significantly among the groups (Kruskal-Wallis: P = 0.0029). The women with early menopause bad a lower trabecular bone density than the women with normal and late menopause (P = 0.0019 and P < 0.0001, respectively). Among the women with early menopause, 22 had experienced menopause before the age of 40 and 25 after the age of 40; there were significant differences in trabecular bone mineral density between these two subgroups (P < 0.05). Trabecular bone mineral density, the only variable studied that varied among the groups, correlated significantly with the duration of reproductive life (simple linear regression: r = 0.340, P < 0.0001). In conclusion, these findings emphasize the importance of the duration of reproductive life as a determinant of bone mass in women. |
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