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The mechanochemical preparation of solid disperse systems of ibuprofen-polyethylene glycol
Institution:1. School of Defense Science, Chung Cheng Institute of Technology, National Defense University, Dasi 335, Taiwan;2. Department of Photonics Engineering, Yuan Ze University, Chungli 320, Taiwan;3. Chemical System Research Division, Chung Shan Institute of Science and Technology, Longtan, Taoyuan 325, Taiwan;4. Department of Chemical & Materials Engineering, Chung Cheng Institute of Technology, National Defense University, Dasi 335, Taiwan;1. University of Belgrade, Institute of Chemistry, Technology and Metallurgy, Department of Catalysis and Chemical Engineering, Njegoševa 12, Belgrade, Serbia;2. University of Belgrade, Institute of Nuclear Sciences Vinča, Laboratory for Material Science, P.O. Box 522, Belgrade, Serbia;1. Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa;2. Department of Applied Chemistry, University of Johannesburg, P.O. Box 17011, Doornfontein, 2028 Johannesburg, South Africa;1. Nofima AS - the Norwegian Institute of Food, Fisheries and Aquaculture Research, Osloveien 1, NO-1433 Ås, Norway;2. Departamento de Química-Física I, Facultad de Ciencias Químicas, Universidad Complutense, Madrid 28040, Spain
Abstract:The method of mechanical activation is applied to obtain a solid-state dispersion of ibuprofen in polyethylene glycol (PEG). The release rate and solubility of the drug was found to depend on carrier molecular weight and its weight fraction. The highest release rate and solubility were achieved in systems containing equimolar amounts of the drug and PEG 4000 or PEG 6000. It was shown by IR-spectroscopy and fluorescence measurements that the mechanical treatment gives rise to an interaction between ibuprofen and PEG that was a cause of the effects observed.
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