Effect of Luffa aegyptiaca (seeds) and Carissa edulis (leaves) extracts on blood glucose level of normal and streptozotocin diabetic rats |
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| Institution: | 1. Department of Phalmacognosy, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt;2. Department of Pharmacology, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt;1. School of Animal, Plant and Environmental Sciences, University of the Witwatersrand, Private Bag 3, Wits, 2050, South Africa;2. Department of Forest Resources and Wildlife Management/Forest Ecology Laboratory, Faculty of Applied Sciences, National University of Science & Technology, P.O. Box AC 939 Ascot, Bulawayo, Zimbabwe;3. Department of Mammalogy, Natural History Museum of Zimbabwe, P.O. Box 240, Bulawayo, Zimbabwe;4. Department of Agriculture and Natural Resources Sciences, Faculty of Natural Resources and Spatial Sciences, Namibia University of Science & Technology, Private Bag 13388, Windhoek, Namibia;5. Department of Natural Resources, Bindura University of Science Education, Private Bag 1020, Bindura, Zimbabwe;1. Institute of Oceanography and Fisheries, ?etali?te Ivama Me?trovi?a 63, 21000 Split, Croatia;2. Polytechnic University of Marche, Department of Life and Environmental Sciences, Via Brecce Bianche, 60131 Ancona, Italy;3. Faculty of Science, University of Split, Teslina 12, Split, Croatia;4. Boston University, Biological Science Center, 5 Cummington Street, Boston, MA 02215-2406, USA;5. Université de Brest, Institut Universitaire Européen de la Mer, Laboratoire des Sciences de l''Environnement Marin (LEMAR UMR6539 UBO/CNRS/IRD), rue Dumont d''Urville, 29280 Plouzané, France;1. Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, 3886, South Africa;2. Department of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, 60121, Italy;3. Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council, Tygerberg, 7505, South Africa;4. Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Tygerberg, Stellenbosch, South Africa;1. MEF University, Mechanical Engineering Department, 34396 Istanbul, Turkey;2. Marmara University, Vocational School of Technical Sciences, Mechanical Department, 34722 Istanbul, Turkey;1. Licenciatura en Biología, Facultad de Ciencias, UNAM, Circuito Exterior S/N, Coyoacán, 04510, Ciudad Universitaria, CDMX, Mexico;2. Museo de Paleontología, Facultad de Ciencias, UNAM, Circuito Exterior S/N, Coyoacán, 04510, Ciudad Universitaria, CDMX, Mexico;3. Centro de Geociencias, Campus Juriquilla, UNAM. Blvd. Juriquilla 3001, Juriquilla, 76230, Querétaro, Mexico |
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| Abstract: | The present study investigates the effect of oral administration of the ethanolic extracts of Luffa aegyptiaca (seeds) and Carissa edulis (leaves) on blood glucose levels both in normal and streptozotocin (STZ) diabetic rats. Treatment with both extracts significantly reduced the blood glucose level in STZ diabetic rats during the first three hours of treatment. L. aegyptiaca extract decreased blood glucose level with a potency similar to that of the biguanide, metformin. The total glycaemic areas were 589.61 ± 45.62 mg/dl/3 h and 660.38 ± 64.44 mg/dl/3 h for L. aegyptiaca and metformin, respectively, vs. 816.73 ± 43.21 mg/dl/3 h for the control (P < 0.05). On the other hand, in normal rats, both treatments produced insignificant changes in blood glucose levels compared to glibenclamide treatment. |
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