Preliminary studies of analgesic and anti-inflammatory properties of Caesalpinia ferrea crude extract |
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| Affiliation: | 1. Department of Neuroscience and Behavioral Science, University of Sao Paulo (USP) — Ribeirao Preto, SP, CEP 14048-900, Brazil;2. Department of Biophysics Pharmacology, Federal University of Rio Grande do Norte (UFRN), Natal, RN CEP 59012420, Brazil;3. Neurochemical Research Unit, Department of Psychiatry, University of Alberta, 12-105B CSB, Edmonton, AB T6G 2G3, Canada;1. Department of Medical Oncology, Institut Bergonié, Bordeaux;2. Department of Medicine, Institut Gustave Roussy, Villejuif;3. Department of Medicine, Institut Curie, Paris;4. Department of Medicine, Centre Oscar Lambret, Lille;5. Department of Medicine, Institut Claudius Regaud, Toulouse;6. Department of Medical Oncology, Hôpital La Timone, Marseille;7. Clinical and Epidemiological Research Unit, Institut Bergonié, Bordeaux;8. Data Center for Cancer Clinical Trials, CTD-INCa, Bordeaux, France;1. Núcleo de Cognição e Sistemas Complexos, Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, Brazil;2. Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil;3. Institute of Physics, Humboldt University at Berlin, Germany;4. Departamento de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil;5. Núcleo de Cognição e Sistemas Complexos, Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Brazil |
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| Abstract: | The crude aqueous extract of the fruits of Caesalpinia ferrea Mart. (Leguminosae) has been investigated for possible anti-inflammatory and analgesic properties. The carrageenan induced rat hind paw edema was significantly inhibited (P < 0.05) by oral administration of 300 mg/kg of this extract. A centrally mediated analgesic effect was not observed, however, there was a dose dependent reduction in the number of total writhes induced by acetic acid. |
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