A small volume spacer for use with a breath-operated pressurised metered dose inhaler |
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| Affiliation: | 1. China National Tobacco Quality Supervision and Test Center, High and New Technology Industries Development Zone, No.6 Cuizhu Street, Zhengzhou 450001, China;2. School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu Province 212003, China;3. Yunnan Institute of Tobacco Quality Inspection & Supervision, Kunming 650106, China;4. School of Materials Science and Engineering, Peking University, Beijing 100871, China;5. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore |
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| Abstract: | A small volume spacer, the Optimiser, has been evaluated for use with the Easi-Breathe breath-operated inhaler. Oropharyngeal deposition in healthy subjects was reduced by 80% by the use of the spacer. The Optimiser spacer removes most of the non-respirable drug, without compromising the fine particle dose delivered from the Easi-Breathe inhaler. |
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