Protective effect of UL-409, a herbal formulation against physical and chemical factor induced gastric and duodenal ulcers in experimental animals |
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| Institution: | 1. Laboratory of Biochemistry, Research Unit: UR 12ES08 “Cell Signaling and Pathologies”, Faculty of Medicine, University of Monastir, Tunisia;2. Laboratory of Development of Drugs (LR12ES09), Marine Pharmacology Team, Faculty of Pharmacy of Monastir, University of Monastir, 5000 Monastir, Tunisia;1. Andalusian Institute of Earth Sciences, CSIC-University of Granada, Avda. de las Palmeras 4, Armilla, 18100 Granada, Spain;2. Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Campus of Cartuja s/n, 18071 Granada, Spain;1. Vascular and Interventional Radiology Center, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital/The Johns Hopkins University, 1800 Orleans Street, Baltimore, MD 21287, United States;2. Department of Health, Behavior and Society, The Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, 550 N. Broadway, Baltimore, MD 21205, United States;3. Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital/The Johns Hopkins University, 600 N. Wolfe Street, Baltimore, MD 21287, United States;4. Division of Interventional Radiology, Piedmont Radiology, 1984 Peachtree Road, Atlanta, GA 30309, United States;1. Centro de Investigación en Biotecnología. Universidad Autónoma del Estado de Morelos. Av. Universidad 1001. Col. Chamilpa. Cuernavaca 62209, Morelos, México;2. Departamento de Bioquímica. Facultad de Medicina. Universidad Nacional Autónoma de México. Ciudad Universitaria, México 04510, D.F. México;3. Facultad de Ciencias Biológicas. Universidad Autónoma del Estado de Morelos, Morelos, México;1. Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;2. Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;3. School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan;4. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan;5. Division of Basic Medical Sciences, Department of Nursing, Chang Gung Institute of Technology and Chronic Diseases and Health Promotion Research Center, Chiayi, Taiwan;6. Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan;7. Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan;8. Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan;1. Programa de Pós-Graduação em Ciências Farmacêuticas (PPGCF), Núcleo de Investigacões Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí (UNIVALI), Rua Uruguai, 458, Centro, 88302-202 Itajaí, SC, Brazil;2. Instituto de Pesquisa Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, 80250-200 Curitiba, Paraná, Brazil |
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| Abstract: | UL-409, a herbal formulation, was investigated for its possible ulcero-protective activity in Wistar rats of either sex and male guinea pigs. Oral administration of UL-409 at a dose of 600 mg/kg significantly prevented the occurrence of cold-restraint stress induced ulcerations. It significantly inhibited gastric ulceration induced by alcohol and aspirin, as well as cysteamine and histamine induced duodenal ulcers in rats and guinea pigs, respectively. The volume and acidity of gastric juice in pyloric ligated rats was reduced by UL-409. It also significantly, and dose dependently, promoted gastric mucus secretion in normal as well as in stress, drug and alcohol induced ulceration in animals. On the basis of these observations, we conclude that UL-409 possesses antiulcer activity and that the observed activity may be due to the modulation of defensive factors by improvement in gastric cytoprotection. |
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