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Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression
Authors:Ruiz-Velasco Natividad  Domínguez Angeles  Vega Miguel A
Affiliation:Servicio de Bioquímica-Investigación, Consejo Superior de Investigaciones Científicas, Hospital Ramón y Cajal, Ctra. Colmenar Viejo km. 9.1, 28034, Madrid, Spain.
Abstract:
Keywords:15dPJ2, 15-deoxy-Δ12,14-Prostaglandin J2   AGE, advance glycation endproducts   eNOS, endothelial nitric oxide synthase   HMG-CoA, 3-hydroxy-3-methylglutaryl coenzyme A   FCS, fetal calf serum   FOH, trans-trans farnesol   GGOH, all-trans geranyl geraniol   LDL, low-density lipoprotein   LPA, lysophosphatidic acid   OxLDL, oxidized low-density lipoprotein   PAI-1, plasminogen activator inhibitor-1   PPAR, peroxisome proliferator-activated receptor   SREBP, sterol regulatory element-binding protein   tPA, tissue plasminogen activator
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