| 咬合力减弱对大鼠磨牙牙周膜Ⅰ型胶原mRNA表达的影响 |
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| 摘 要： |
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| 关 键 词： | 牙周膜 Ⅰ型胶原 原位杂交 咬合力 mRNA |
Effect of decreased bite force on the temporal and spatial expression of type I collagen mRNA in rat molar periodontal ligament] |
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| Authors: | F Liu Y Zhao M Li G Li H Wang |
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| Institution: | Department of Prothodontics, School of Stomatology, WCUMS, Chengdu 610041, China. |
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| Abstract: | OBJECTIVE: The aim of this study was to observe the effect of decreased bite force on type I collagen mRNA in periodontal ligament (PDL) and probe into the molecular mechanism of the change in type I collagen mRNA. METHODS: Animal models were established by extracting left maxillary molars of rats. In situ hybridization was applied. RESULTS: The results showed that under decreased bite force, the expression level of type I collagen mRNA decreased at the sixth hour (49.7 +/- 11.1) (P < 0.05), reached the nadir on the second day (23.7 +/- 8.6), began to get over on the third day (43.1 +/- 10.3), and reached a relatively high level at the second week(56.3 +/- 9.8), but it was still lower than that of the normal bite force group (91.4 +/- 16.0)(P < 0.05); the expression of type I collagen mRNA near the cementum was higher than that near the alveolar bone. CONCLUSION: These results indicate that the expression level of type I collagen mRNA is closely related to bite force. |
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