Serum insulin level,HOMA-IR and prostate cancer risk: A systematic review and meta-analysis |
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Authors: | Somayeh Saboori Esmaeil Yousefi Rad Mehdi Birjandi Sara Mohiti Ebrahim Falahi |
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Affiliation: | 1. Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran;2. Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran;3. Department of Nutrition, Qazvin University of Medical Sciences, Qazvin, Iran |
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Abstract: | AimsThis meta-analysis study was performed to assess serum insulin level and insulin resistance status in prostate cancer patients in observational studies.Materials and methodsA systematic literature search was performed for observational studies in Scopus, PubMed, Ovid and ISI Web of Science up to July 2017.ResultsFrom 2070 publication were searched firstly, only 10 studies with 9 and 6 arms included for the meta-analysis assessing serum insulin level and HOMA-IR status in prostate cancer patients, respectively. Pooled effects analysis showed that the Fasting insulin level was significantly higher in men with prostate cancer compared to control group (WMD = 2.12 μ IU/ml, 95%CI; 0.26, 3.99; P = 0.02). Sub-group analysis showed that the elevation in serum insulin level takes place only in patients with ages more than 65 years old (WMD = 3.88 μ IU/ml, 95%CI; 2.28, 5.48; P < 0.001). HOMA-IR was no significantly different between study groups. However, the difference got statistically significant after sub-grouping patients based on their age (WMD = 1.37, 95% CI; 0.61, 2.12; P < 0.001).ConclusionIn conclusion, the results of this meta-analysis study showed higher fasting serum insulin and HOMA-IR levels especially in patients with ages more than 65 years.. |
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Keywords: | Corresponding author. Insulin resistance HOMA-IR Prostate cancer Meta-analysis |
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