Neuropathic diabetic foot ulcers treated with cerium dioxide nanoparticles: A case report |
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| Authors: | Nazarii Kobyliak Ludovico Abenavoli Liudmyla Kononenko Dmytro Kyriienko Mykola Spivak |
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| Affiliation: | 1. Bogomolets National Medical University, T. Shevchenko Boulevard, 13, Kyiv, 01601, Ukraine;2. Department of Health Sciences, University Magna Graecia of Catanzaro, Italy;3. Kyiv City Clinical Endocrinology Center, Pushkinska 22a, Kyiv, 01601, Ukraine;4. Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Zabolotny Str., 154, Kyiv, 03680, Ukraine;5. LCL “DIAPROF”, Svitlycky Str., 35, Kyiv, 04123, Ukraine |
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| Abstract: | ![]()
Wound healing in diabetes is frequently impaired and its treatment remains a challenge. The ability of topical application of cerium (Ce) dioxide nanoparticles (CNPs) to accelerate wound healing in an animal model provides a rationale to develop this technology for use in humans affected by traumatic injury, diabetes and burns. We first described a case report of successful topical treatment of neuropathic diabetic foot ulcers with novel gel containing CNPs. The CNPs has bacteriostatic activity, anti-inflammatory properties and can penetrated into the wound tissue and reduced oxidative damage therefore protect regenerative tissue, suggesting a therapeutic potential for topical treatment of diabetic foot ulcers. |
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| Keywords: | Corresponding author. Endocrinology Department, Bogomolets National Medical University, Kyiv, 01601, Pushkinska 22a str., Ukraine. Diabetic foot Neuropathic ulcers Pressure ulcers Cerium dioxide nanoparticles |
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