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Myasthenia gravis after allogeneic bone marrow transplantation: A case report and literature review
Authors:Yutaka Tsutsumi  Takashi Kamiishi  Ryo Kikuchi  Shinichi Ito  Satomi Matsuoka  Takanori Teshima
Affiliation:1. Department of Hematology, Hakodate Municipal Hospital, Hakodate, Japan;2. Department of Hematology, Hokkaido Graduate School of Medicine, Sapporo, Japan
Abstract:A 52-year-old man with acute myeloid leukemia underwent allogeneic hematopoietic stem cell transplantation and developed extensive chronic graft-versus-host disease and myasthenia gravis (MG), which became involved with oculobulbar and proximal upper and lower limb weakness in 677 days. In the literature, we identified 24 cases where MG developed after allo-SCT. Graft-versus-host disease development and male recipients of female donors might be prone to the development of posttransplant MG (odds ratio, 3.75).
Keywords:Corresponding author at: Department of Hematology, Hakodate Municipal Hospital, 1-10-1, Minato-Cho, Hakodate 041-8680, Japan.  Acetylcholine receptor antibody  Allogeneic stem cell transplantation  Chronic GVHD  Myasthenia gravis
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