Myasthenia gravis after allogeneic bone marrow transplantation: A case report and literature review |
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Authors: | Yutaka Tsutsumi Takashi Kamiishi Ryo Kikuchi Shinichi Ito Satomi Matsuoka Takanori Teshima |
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Affiliation: | 1. Department of Hematology, Hakodate Municipal Hospital, Hakodate, Japan;2. Department of Hematology, Hokkaido Graduate School of Medicine, Sapporo, Japan |
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Abstract: | A 52-year-old man with acute myeloid leukemia underwent allogeneic hematopoietic stem cell transplantation and developed extensive chronic graft-versus-host disease and myasthenia gravis (MG), which became involved with oculobulbar and proximal upper and lower limb weakness in 677 days. In the literature, we identified 24 cases where MG developed after allo-SCT. Graft-versus-host disease development and male recipients of female donors might be prone to the development of posttransplant MG (odds ratio, 3.75). |
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Keywords: | Corresponding author at: Department of Hematology, Hakodate Municipal Hospital, 1-10-1, Minato-Cho, Hakodate 041-8680, Japan. Acetylcholine receptor antibody Allogeneic stem cell transplantation Chronic GVHD Myasthenia gravis |
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