干扰素α-2b联合阿德福韦酯治疗慢性乙型肝炎临床观察

目的观察干扰素Ⅸ一2b联合阿德福韦酯治疗慢性乙型肝炎的疗效。方法将78例慢性乙型肝炎患者随机分为对照组和观察组各39例，对照组单用德福韦酯治疗，观察组给予干扰素仅一2b和阿德福韦酯联合治疗，比较两组治疗效果。结果对照组总有效率为84．62％，观察组总有效率为94．87％，两组比较差异有统计学意义（P〈0．05）；观察组ALT复常率、HBeAg和HBV—DNA转阴率及HBeAg／，HBeAb转换率均显著高于对照组（P〈0．05）。结论干扰素d一2b联合阿德福韦酯治疗慢性乙型肝炎疗效优于单用阿德福韦酯，可提高患者ALT复常率、HBeAg和HBV—DNA转阴率，值得推广应用。

Clinical observation on the therapeutic effect of interferon a-2b and ade- fovir dipivoxil in the treatment of chronic hepatitis B

Objective To explore the therapeutic effect of interferon（INF）α-2b and adefovir dipivoxil in the treatment of chronic hepatitis B. Methods A total of 78 patients with chronic hepatitis B were randomly divided into control group and observation group, each of 39 eases. Control group was treated with adefovir dipivoxil while observation group was treated with INF ol-2b and adefovir dipivoxil. The efficacy of the two groups were observed. Results After treatment, the total effective rate of control group and observation group were 84.62%, 94.87%, had statistically signif- icant difference （P 〈 0.05）. The normalization rate of ALT and the negative rate of HBeAg and HBV-DNA in observa- tion group were significantly higher than the control group （P 〈 0.05）. Conclusion INF a-2b and adefovir dipivoxil combination therapy has better efficacy on chronic hepatitis B than adefovir dipivoxil monotherapy, it can improve nor- malization rate of ALT and the negative rate of HBeAg and HBV-DNA, is worthy of promotion and application.