| 锌影响鼠脑发育及金属硫蛋白表达的细胞分析 |
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| 引用本文： | 刘树刚,孔祥英.锌影响鼠脑发育及金属硫蛋白表达的细胞分析[J].营养学报,1998,20(2):163-167. |
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| 作者姓名： | 刘树刚 孔祥英 |
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| 作者单位： | 第三军医大学西南医院儿科，河北医科大学肿瘤研究所 |
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| 摘 要： | 方法：建立低锌、常锌及高锌动物（生后４周及７周）模型，用流式细胞分析技术，对幼鼠脑神经细胞的增殖周期、ＤＮＡ和总蛋白的含量及金属硫蛋白（Ｍｅｔａｌ－ｌｏｔｈｉｏｎｅｉｎ，ＭＴ）的表达进行了测定。结果：低锌组及高锌组与常锌组相比，细胞增殖周期、ＤＮＡ和总蛋白含量及ＭＴ表达有显著差异（Ｐ＜０．０５或Ｐ＜０．０１）。结论：锌明显影响幼鼠脑发育，且与ＭＴ表达密切相关
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| 关 键 词： | 锌 脑 发育 金属硫蛋白 细胞分析 |
CELL ANALYSIS OF EFFECT OF ZINC ON YOUNG RAT BRAIN DEVELOPMENT AND MT EXPRESSON |
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| Liu Shugang,Kong Xiangying,Zuo Lianfu,Guo Jianwen.CELL ANALYSIS OF EFFECT OF ZINC ON YOUNG RAT BRAIN DEVELOPMENT AND MT EXPRESSON[J].Acta Nutrimenta Sinica,1998,20(2):163-167. |
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| Authors: | Liu Shugang Kong Xiangying Zuo Lianfu Guo Jianwen |
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| Abstract: | The model of zinc deficiency (ZD), zinc normal (ZN) and zinc excess(ZE) were established in young rats (age of 4 and 7 wks) to investigate the influence of Zn on proliferative index, expression of metallothionein (MT) and the content of DNA and protein in brain cells by flow cytometry technique. Results indicated that cell proliferative index, MT expression and content of DNA and protein in ZD and ZE group were significantly different from those in ZN group. It was suggested that Zn markedly influenced the development of young rat brain, and greatly related to the expression of MT. |
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| Keywords: | zinc brain development metallothionein (MT) cell analysis |
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