Autophagy Activity in Pulmonary Metastatic Tumor Tissues from Colorectal Cancer: A Pilot Study |
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| Authors: | Young Sam Kim Ju Hye Shin Mi Kyung Bae Chang Young Lee Dae Joon Kim Kyung Young Chung Jin Gu Lee |
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| Affiliation: | 1.Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.;2.Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul, Korea. |
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| Abstract: | PurposeAutophagy has been reported to be involved in treatment failure in tumor. We aimed to evaluate autophagy activity in tumor tissue and compare them between the recurrence and non-recurrence groups.Materials and MethodsWe analyzed expressions of autophagy-related proteins in tumor tissues which were obtained from pulmonary metastases of colorectal cancer patients by Western blot. We also analyzed autophagosomes by transmission electron microscopy.ResultsTumor tissues from recurrence group showed increased levels of LC3B-II, decreased levels of p62/SQSTM1, and also a marked accumulation of autophagosomes compared with tissues from non-recurrence group.ConclusionThe present study suggests that autophagy may be associated with treatment failure of metastatic colorectal cancer. |
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| Keywords: | Colorectal cancer metastasis treatment failure autophagy |
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