SAA、hs-CRP及NLR在NCP患者早期诊断的临床意义

目的探讨血清淀粉样蛋白A(SAA)、超敏C反应蛋白(hs-CRP)及中性粒细胞/淋巴细胞比值(neutrophil tolymphocyte ratio,NLR)在新型冠状病毒肺炎(NCP)患者早期诊断的临床意义。方法选择我院住院的NCP患者46例,其中男29例,女17例,其中分为单纯轻型NCP轻型患者①组15例(男8例,女7例),NCP普通型患者②组22例(男13例,女9例:包括胃炎、呼吸道感染、心功能不全、甲状腺肿瘤、膀胱肿瘤、结核等),NCP重型患者③组9例(男8例,女1例:包括高血压、糖尿病、结缔组织病等),另外选择健康查体者40人(男20例,女20例)作为对照组,对比分析各项检查指标在早期的诊断价值。结果NCP患者组SAA、hs-CRP、NLR及血沉(ESR)结果明显高于对照组(P<0.01),其中重型患者组高于普通型患者组合轻型组患者组(P<0.01),患者三组之间结果差异显著(P<0.01)。结论SAA、hs-CRP、NLR及ESR在NCP患者疾病早期诊断中效果优于检验普通检查,可作为临床诊断的指标之一。

Clinical significance of SAA,hs-CRP and NLR in early diagnosis of NCP

Objective Novel coronavirus pneumonia(NCP)patients were diagnosed by serum amyloid A(SAA),high sensitivity C reactive protein(hs-CRP)and neutrophil/lymphocyte ratio(NLR).Methods We selected 46 NCP patients in our hospital,including 29 males and 17 females.Among them,15 patients(8 males and 7 females)were divided into simple light NCP and light NCP group;22 cases(13 males,9 females,including gastritis,respiratory tract infection,cardiac insufficiency,thyroid tumor,bladder tumor,tuberculosis,etc.)of NCP group 2;9 cases(8 males,1 female,including hypertension,diabetes,connective tissue disease,etc.)in group③of NCP.In addition,40 healthy examiners(20 males and 20 females)were selected as the control group.Results To compare and analyze the diagnostic value of each index in early stage.Results the results of SAA,hs-CRP,NLR and ESR in NCP group were significantly higher than those in control group(P<0.01).Among them,the severe group was higher than the light group(P<0.01),There was significant difference among the three groups(P<0.01).Conclusion SAA,hs-CRP,NLR and ESR are better than general examination in the early diagnosis of NCP patients,and can be used as one of the indicators of clinical diagnosis.