Variations in Irisin,Bone Mineral Density,Bone Mineral Content,and Body Composition After Laparoscopic Bariatric Procedures in Obese Adults |
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| Institution: | 1. Science and Education Office, The First Affiliated Hospital, Jinan University, Guangzhou, China;2. Medical Centre of Stomatology, The First Affiliated Hospital, Jinan University, Guangzhou, China;3. Department of Internal Medicine, The First Affiliated Hospital, Jinan University, Guangzhou, China;4. Department of Endocrinology, The First Affiliated Hospital, Jinan University, Guangzhou, China;5. Department of General Surgery, The First Affiliated Hospital, Jinan University, Guangzhou, China;1. Unità Operativa di Radiologia Diagnostica ed Interventistica, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy;2. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy;3. Scuola di Specializzazione in Radiodiagnostica, Università degli Studi di Milano, Milan, Italy;4. Bone Metabolic Unit, Fondazione IRCCS Ca'' Granda Ospedale Maggiore Policlinico, Medicina Nucleare, Milan, Italy;1. Université Clermont Auvergne, Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), Clermont-Ferrand, France;2. School of Exercise Science, Australian Catholic University, Strathfield, NSW, Australia;3. Faculty of Health, Australian Catholic University, Melbourne, VIC, Australia;4. Université Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, Occupational and Preventive Medicine, WittyFit, Clermont-Ferrand, France;5. UGECAM, SSR Nutrition-Obesity, Clermont-Ferrand, France;6. CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, the Clinical Research and Innovation Direction, Clermont-Ferrand, France;7. Université Clermont Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, Sports Medicine, Clermont-Ferrand, France;8. CRNH Auvergne, Clermont-Ferrand, France |
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| Abstract: | Introduction: This study was aimed to assess irisin levels in obesity (OB) and T2DM individuals and investigate the dynamic changes of irisin, bone mineral density (BMD), bone mineral content, and body composition in 19 OB patients after laparoscopic bariatric procedures, and also to evaluate the correlation of irisin, with BMD and body composition. Methods: Forty-five OB, 20 T2DM, and 20 healthy adults had been recruited. Levels of irisin were measured in all subjects. Metabolic characteristics were obtained from OB and T2DM patients. Nineteen patients were randomly assigned to be received Roux-en-Y gastric bypass (LRYGB) or laparoscopic sleeve gastrectomy (LSG) procedure and to be completed 6-month follow-up. Irisin, BMD, bone mineral content, and body composition were measured at each visit. Results: Significantly higher circulating irisin levels were measured in the OB group compared with T2DM and control groups. FINS, C-P, HOMA-IR, FBCI, HBCI, ALT, AST, and UA levels of OB were significantly higher than those of T2DM patients. While FBG and HbA1c of the OB were significantly lower than T2DM group. There were significant differences among circulating irisin, BMD, and body composition after laparoscopic bariatric surgery. Levels of irisin were decreased after operations including both LRYGB and LSG surgery compared with preoperation. At each time point (1, 3, and 6 months) of postoperation, there was no significant difference in percentage of total weight loss between LSG and LRYGB group. The positive correlation of irisin levels with total BMD, muscle, and fat masses were found during 6-month follow-up after surgery. Conclusions: The levels of irisin were higher in OB patients. There were positive correlations of irisin levels with total BMD, muscle, and fat masses during 6-month follow-up after surgery. Irisin may be involved in the occurrence and development of obese and it is related to BMD and body composition. Both LRYGB and LSG operations could decrease the circulating levels of irisin. |
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