乳腺神经内分泌癌的临床病理特征及预后分析

目的：分析乳腺神经内分泌癌的临床病理学特征及预后因素。方法收集43例乳腺神经内分泌癌的临床资料和生存情况，分析其临床病理特点和预后因素。结果所有患者中位随访时间48个月（8～90个月），患者5年总生存率为67％。单因素分析显示腋窝淋巴结转移（P＝0．037）、较晚的TNM分期（P＝0．005）、较高的组织学分级（P＝0．005）和Ki-67高表达（P＝0．040）与患者生存差相关，多因素分析显示仅组织学分级（P ＝0．022）是患者预后的独立因素。结论乳腺神经内分泌癌是一类具有特殊临床病理特征的乳腺癌，常用的临床病理学指标中仅组织学分级是其独立预后因素。

Analysis of the clinicopathologic features and prognosis of neuroendocrine cancer of the breast

Objective To investigate the clinicopathologic features and prognostic factors of primary neuroendocrine cancer of the breast（NECB）.Method The clinical data and survival status of 43 cases of NECB were collected to analyze clinicopathologic characteristics and prognostic factors.Result The median follow-up for all patients with NECB was 48 months（range,8～90 months）.The 5-year overall survival rate was 67%.Univariate analysis showed that the presence of regional lymph node metastasis（P=0.037）,advanced TNMstage（P=0.005）,advanced histological grade（P=0.005）and high level of Ki-67（P=0.040）were correlated with the poor overall survival.However,multivariate analysis showed that only histological grade（P=0.022）was the independent prognostic factor.Conclusion NECB is a subtype of mammary carcinoma with several distinctive clinicopathologic features.Among the common used clinicopathologic factors,histological grade is the only independent prognostic predictor of the survival of NECB.