Threshold of seizure activity of the brain and higher nervous activity in the postresuscitation period for intracerebral allotransplantation of fetal neocortex tissue |
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Authors: | V V Semchenko S I Ereniev K K Makovetskii |
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Institution: | (1) Department of Histology and Embryology, Omsk State Medical Academy, Omsk, USSR |
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Abstract: | The threshold of seizure activity of the brain, long-term memory, and learning ability are studied in Wistar rats for bilateral
transplantation of fetal nervous tissue in area CA1 of the hippocampus. The grafts are performed on the 2nd, 7th, 14th and
30th days after clinical death caused by asphyxia. A neurotransplantation performed on the 2nd day of the postresuscitation
period is found to prevent seizure activity, whereas that performed on the 7th–14th days results in a sharp decline or cessation
of spontaneous and induced epileptiform convulsive seizures, prolonged preservation of the long-term memory trace, an improvement
of learning ability, and a lessening of defensive and phobic behavior in a large proportion of the animals.
Translated fromByulleten's Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
2, pp. 234–237, February, 1996
Presented by V. A. Negovskii, Member of the Russian Academy of Medical Sciences |
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Keywords: | seizure activity higher nervous activity postresuscitation period fetal nervous tissue transplantation |
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