Development and characterization of a human ovarian cancer cell line which clones without agar in vitro |
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| Authors: | G Clamon P M Loh M White R Robinson |
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| Affiliation: | 1. Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242 USA;2. Department of Surgery, University of Iowa College of Medicine, Iowa City, Iowa 52242 USA;3. Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242 USA |
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| Abstract: | A new human ovarian cancer cell line has been initiated which clones without agar in vitro. The cell line has been characterized by growth of a tumor resembling the primary tumor in a nude mouse, by human lactic dehydrogenase isozyme pattern, by human karyotype, and by lack of contamination by other cell lines. Initial studies have demonstrated the presence of epidermal growth factor receptors in this cell line. The utility of this line for clonogenic studies is demonstrated by dose-response studies with doxorubicin, cisplatinum, and 13-cis-retinoic acid. |
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| Keywords: | To whom reprint requests should be addressed: Department of Internal Medicine University of Iowa Hospitals Iowa City Iowa 52242. |
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