前列地尔干乳剂对非ST段抬高急性心肌梗死心功能的改善作用

目的 探讨前列地尔干乳剂对非ST段抬高急性心肌梗死(NSTEMI)患者心功能的改善作用.方法 选择我院心内科2014年1月至2016年4月期间收治的50例NSTEMI患者作为研究对象,根据随机数字表法随机分为两组,各25例,对照组予常规阿司匹林+氯吡格雷抗血小板治疗,观察组联合应用前列地尔干乳剂,疗程14 d;观察两组患者治疗前后的血清脑钠肽(BNP)浓度及左心室射血分数(LVEF)的变化,并比较主要心脏不良事件发生情况.结果 治疗后,观察组与对照组患者血清BNP分别为(152.2±60.1)pg/mL、(245.4±73.5)pg/mL,均较治疗前的(590.4±137.8)pg/mL、(601.2±139.4)pg/mL明显下降,LVEF分别为(49.6±6.2)%、(45.3±6.4)%,均较治疗前的(40.2±6.3)%、(41.5±4.6)%明显升高,且观察组优于对照组,差异均有统计学意义(P<0.05);观察组患者再发心衰率为4.0%,明显低于对照组的24.0%,差异有统计学意义(P<0.05).结论 前列地尔干乳剂应用于非ST段抬高急性心肌梗死的治疗,可通过扩血管、抗血小板聚集等作用显著改善患者的心功能,进而改善患者的预后.

Improvement effect of alprostadil dry emulsion on cardiac function in patients with non ST-segment elevation myocardial infarction

Objective To investigate the improving effect of alprostadil dry emulsion on cardiac function in pa-tients with non ST-elevation myocardial infarction (NSTEMI). Methods A total of 50 patients with NSTEMI who treat-ed in Department of Cardiology in our hospital from January 2014 to April 2016 were selected as the research object. They were divided into two groups (control group and observation group) according to random number table, with 25 pa-tients in each group. The control group received routine aspirin plus clopidogrel antiplatelet therapy, and the observation group was treated with alprostadil dry emulsion, with treatment for 14 days. The changes of serum brain natriuretic pep-tide (BNP) concentration and left ventricular ejection fraction (LVEF) were compared between the two groups before and after treatment, and the incidence of major adverse cardiac events were compared. Results After treatment, the se-rum BNP in observation group and the control group were respectively (152.2±60.1) pg/mL, (245.4±73.5) pg/mL, which were significantly lower than those before treatment of (590.4 ± 137.8) pg/mL, (601.2 ± 139.4) pg/mL. After treatment, LVEF in two groups were respectively (49.6±6.2)%and (45.3±6.4)%, which were significantly higher than those before treatment of (40.2±6.3)%and (41.5±4.6)%, while the observation group was better than control group (P<0.05). The re-current heart failure rate in observation group was 4.0%, which was significantly lower than that in control group of 24.0%, P<0.05. Conclusion Alprostadil dry emulsion can significantly improve the cardiac function for patients with NSTEMI by expanding blood vessels and anti-platelet aggregation, and to improve the prognosis.