男性冠心病患者血清高敏C反应蛋白及尿酸水平的变化及其临床意义

目的 检测分析男性冠心病(CHD)患者血清高敏C反应蛋白(hs-CRP)和尿酸水平变化及其临床意义.方法 收集2016年1~7月本院心内科男性CHD住院患者158例,其中稳定性心绞痛(SA)55例、不稳定性心绞痛(UA)67例、急性心肌梗死(AMI)36例.收集同时期心内科因胸闷胸痛症状住院,经冠状动脉造影技术排除CHD的男性患者54例作为对照组.采用免疫比浊法检测所有患者血清hs-CRP和尿酸浓度,统计学分析二者水平在男性CHD各组及对照组间的差异.结果 男性CHD患者AMI组、UA组、SA组及对照组血清hs-CRP浓度依次为(44.86±48.30)mg/mL、(8.38±13.26)mg/mL、(0.75±0.74)mg/mL、(0.79±1.27)mg/mL,AMI组水平明显高于UA组、SA组及对照组,且UA组高于SA组和对照组,差异均具有显著统计学意义(P<0.01).男性CHD患者AMI组、UA组、SA组及对照组血清尿酸浓度依次为(345.66±118.82)mg/mL、(403.45±95.86)mg/mL、(343.25±75.09)mg/mL、(339.48±58.28)mg/L,UA组血清尿酸水平明显高于SA组、AMI组和对照组,差异均具有统计学意义(P<0.05).结论 血清hs-CRP和尿酸水平与男性CHD的发生发展关系密切,对于诊断评估男性CHD有一定的价值.

Changes of the serum high-sensitivity C-reactive protein and uric acid level in male patients with coronary heart disease and its clinical significance

Objective To investigate the changes of the serum high-sensitivity C-reactive protein (hs-CRP) and uric acid (UA) level in male patients with coronary heart disease (CHD) and its clinical significance. Methods A total of 158 male patients with CHD in Department of Cardiology in our hospital from January 2016 to July 2016 were select-ed. They were divided into three groups:stable angina (SA group, n=55), unstable angina (UA group, n=67), acute myo-cardical infarction (AMI group, n=36). Another 54 subjects who admitted to the hospital due to chest pain and chest pain were enrolled in the same period without CHD were taken as controls (control group). The serum levels of hs-CRP and UA were measured by immune turbidimetry in all patients. The difference of hs-CRP and UA level in CHD patients and control group were statistically analyzed. Results The serum hs-CRP levels of AMI group was (44.86±48.30) mg/mL, which was significantly higher than that in UA group (8.38 ± 13.26) mg/mL, SA group (0.75 ± 0.74) mg/mL and control group (0.79 ± 1.27) mg/mL, and the level UA group was significantly higher than that in SA group and control group, with statistically significant difference (P<0.01). The serum UA levels of UA group was (403.45 ± 95.86) mg/mL, which was significantly higher than that in SA group (343.25±75.09) mg/mL, AMI group (345.66±118.82) mg/mL and control group (339.48 ± 58.28) mg/mL, with statistically significant difference (P<0.01). Conclusion Serum levels of hs-CRP and UA are closely related to the occurrence and development of male CHD, which has clinical value in the diagnosis of male CHD.