微量元素及氧化应激指标在社区获得性肺炎儿童中的检测价值

目的 研究与分析微量元素及氧化应激指标在社区获得性肺炎儿童中的检测价值.方法 选取2015年9月至2016年6月期间本院收治的60例社区获得性肺炎患儿为观察组,并选取同时期的60例同龄健康儿童为对照组,检测及比较两组儿童的血清微量元素及氧化应激指标,并比较不同严重程度与病程分期肺炎儿童的血清微量元素及氧化应激指标,采用Logistic分析上述指标与本病患儿的关系.结果 观察组患儿的血清锌(Zn)、铁(Fe)及镁(Mg)水平分别为(10.24±0.96)μmol/L、(2.52±0.30)mmol/L及(0.78±0.06)mmol/L,均低于对照组的(14.21±1.28)μmol/L、(4.66±0.50)mmol/L及(1.22±0.13)mmol/L,血清氧化应激指标血清总抗氧化力(TAC)、晚期氧化蛋白产物(AOPP)、过氧化氢酶(CAT)及超氧化物歧化酶(SOD)水平分别为(10.40±1.10)kU/L、(198.78±17.63)μmol/L、(38.98±3.72)nU/mL及(71.85±5.60)nU/mL,均低于对照组的(13.66±1.53)kU/L、(145.56±13.80)μmol/L、(45.20±4.46)nU/mL及(82.50±6.41)nU/mL,差异均有统计学意义(P<0.05),且不同严重程度与病程分期肺炎患儿的血清微量元素及氧化应激指标也存在明显差异,经Logistic分析结果显示,上述微量元素及氧化应激指标均与本病有密切的关系(P<0.05).结论 微量元素及氧化应激指标在社区获得性肺炎儿童中的检测价值较高,对于患儿的诊断与治疗指导均有积极的临床意义.

Investigation on the detection value of trace elements and oxidative stress indexes in the children with community-acquired pneumonia

Objective To investigate and analyze the detection value of trace elements and oxidative stress in-dexes in the children with community-acquired pneumonia. Methods Sixty children with community-acquired pneu-monia in our hospital from September 2015 to June 2016 were selected as the observation group, and 60 healthy children of the same ages at the same time were selected as the control group. Then the serum trace elements and oxidative stress indexes of children in two groups were compared, and the serum trace elements and oxidative stress indexes of children in observation group with different severity degree and disease course stages of pneumonia were detected and compared. The relationship between those indexes and children with the disease were analyzed by the Logistic regression analysis. Results The serum Zn, Fe and Mg of observation group were respectively (10.24±0.96) μmol/L, (2.52±0.30) mmol/L and (0.78±0.06) mmol/L, as compared with (14.21±1.28) μmol/L, (4.66±0.50) mmol/L, (1.22±0.13) mmol/L in the control group. Serum oxidative stress indexes, including total antioxidant capacity (TAC), advanced oxidation protein products (AOPP), catalase (CAT) and superoxide dismutase (SOD), were respectively (10.40±1.10) kU/L, (198.78±17.63) μmol/L, (38.98 ± 3.72) nU/mL and (71.85 ± 5.60) nU/mL, as compared with (13.66 ± 1.53) kU/L, (145.56 ± 13.80) μmol/L, (45.20 ± 4.46) nU/mL, (82.50±6.41) nU/mL in the control group (P<0.05). The serum trace elements and oxidative stress indexes of children in observation group with different severity degree and disease course stages of pneumonia all had significant differences, and the Logistic regression analysis showed that, those trace elements and oxidative stress indexes all had close relationship to the disease, all P<0.05. Conclusion The detection value of trace elements and oxidative stress in-dexes in the children with community-acquired pneumonia are high, so the indexes have active clinical significance for the diagnosis and treatment guidance of the children.