终末期肾病患者血管钙化风险与维生素K2摄入关系的前瞻性研究

目的 探讨维生素K2的摄入对降低血透患者血管钙化风险的效果.方法 根据摄入的维生素K2剂量不同,将2014年1月至2016年9月在我院住院的维持性血液透析的患者75例分为360μg、720μg、1080μg三组,每组25例.采用维生素K2治疗8周,观察各组患者治疗前后生长停滞特异性蛋白6(Gas6)的表达,并探讨其与维生素K2摄入量是否存在浓度相关性.结果 1080μg组患者治疗后Gas6下降率为42.8%,明显高于360μg组的16.4%及720μg组的28.4%,差异均具有显著统计学意义(P<0.01);血液透析患者血液中Gas6水平随着维生素K2摄入剂量的增高,呈现逐渐下降趋势,具有显著相关性(r=-0.24,P<0.01).结论 维生素K2的摄入可有效降低血液透析患者血管钙化的风险.

Relationship between risk of angiosteosis and vitamin K2 intake in patients with end-stage renal disease: a prospective clinical study

Objective To investigate the effect of vitamin K2 intake on reducing the risk of angiosteosis in he-modialysis patients. Methods According to the intake of vitamin K2, 75 patients with hemodialysis in Liuzhou Work-er's Hospital from January 2014 to September 2016 were randomly divided into three groups: 360 μg group, 720 μg group and 1080μg group, with 25 patients in each group. All the patients were treated with vitamin K2 for 8 weeks. Ex-pression of growth arrest-specific protein 6 (Gas6) were observed before and after treatment among three groups, and Its correlation with vitamin K2 concentration were statistically analyzed. Results Gas6 decline rate of 1080 μg group (42.8%) was significantly higher than that of 360μg group (16.4%) and 720μg group (28.4%), P<0.01. Spearman corre-lation analysis showed that there was a negative correlation between the dose of vitamin K2 intake and the change of Gas6 level (r=-0.24, P<0.01). Conclusion Vitamin K2 intake can effectively reduce the risk of vascular calcification in patients with hemodialysis.