Opiate and peptide interaction: effect of enkephalins on morphine analgesia |
| |
| Authors: | N M Lee L Leybin J K Chang H H Loh |
| |
| Affiliation: | 1. Departments of Pharmacology and Psychiatry, Langley Porter Neuropsychiatric Institute, University of California, San Francisco, CA 94143, U.S.A.;1. Peninsula Labs, 611 Taylor Way, Belmont, CA 94002, U.S.A. |
| |
| Abstract: | Interactions between the weakly analgesic enkephalins and morphine on morphine-induced analgesia were studied. Met-enkephalin exhibited morphine analgesia whereas Leu-enkephalin potentiated it. Both Met- and Leu-enkephalin, when tested alone, were not analgesic. The strongly analgesic FK33824 (Sandoz) compound, like Leu-enkephalin, also potentiated morphine analgesia. Tolerance developed to morphine analgesia but not to Met-enkephalin inhibition of morphine analgesia. |
| |
| Keywords: | Morphine Met-enkephalin Leu-enkephalin FK33824 Analgesia |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
