| 模拟失重下大鼠骨和骨髓中人重组骨形成蛋白-2的变化 |
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| 引用本文： | 傅崇建,杨连甲,曹新生,陈希哲,张立藩.模拟失重下大鼠骨和骨髓中人重组骨形成蛋白-2的变化[J].航天医学与医学工程,2001,14(4):295-297. |
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| 作者姓名： | 傅崇建 杨连甲 曹新生 陈希哲 张立藩 |
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| 作者单位： | 1. 第四军医大学口腔医学院病理科,
2. 第四军医大学航空航天医学系, |
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| 基金项目： | 全军医药卫生科研基金资助 (98Z0 83 ) |
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| 摘 要： | 目的：研究模拟失重骨质和骨髓内人重组骨形成蛋白－2（Human recombination bone morphogenetic protein-2,rhBMP-2)形态学的变化，方法：选用SD大鼠，随机配对分为悬吊组和自由活动组（5只／组），实验期为14、28d。组织标本行原位杂交。结果：尾吊组大鼠骨质和骨髓内rhBMP-2的表达明显弱于对照组（P＜0．05）。尾吊组14d rhBMP-2的表达明显强于28d（P＜0．05）。结论大鼠后肢去负荷导数骨和骨髓rhBMP-2含量的降低。
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| 关 键 词： | 失重模拟 人重组骨形成蛋白－2 骨 骨髓 原位杂交 |
| 文章编号： | 1003-0837(2001)04-0295-03 |
| 修稿时间： | 2000年11月10 |
Changes of Human Recombination Bone Morphogenetic Protein-2 in Bone and Marrow in Tail Suspended |
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| C J Fu,L J Yang,X S Cao,X Z Chen,L F Zhang.Changes of Human Recombination Bone Morphogenetic Protein-2 in Bone and Marrow in Tail Suspended[J].Space Medicine & Medical Engineering,2001,14(4):295-297. |
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| Authors: | C J Fu L J Yang X S Cao X Z Chen L F Zhang |
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| Institution: | Department of Oral Pathology, Stomatological collage, The Fourth Military Medical University, Xi'an 710032, China. |
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| Abstract: | Objective To study human recombination bone morphogenetic prot ei n-2(rhBMP-2) change in bone and marrow under simulated weightlessness. M ethod 5 SD rats were tail suspended for 14,28 d with another 5 freely acti ve rats as control.Histological samples were in situ hybridized. Result rhBMP-2 expression of bone and marrow were lower in tail suspended rats tha n control levels(P<0.05). rhBMP-2 expression tail suspended rats in 14 day were higher than that in 28 day suspended group(P<0.05). Conclusion rhBMP-2 levels in rats bone and marrow were lower after tail suspension. |
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| Keywords: | weightlessness simulation human recombination bone morphogenetic protein-2 bone bone marrow hybridization in situ |
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