大鼠肝动脉插管给药途径的建立

目的 建立一种直接向肝脏给药的血管途径，减少药物经过体循环所致的多种器官功能的影响，以便获取药物对肝脏影响的直接证据。方法 手术显微镜下肝固有动脉插管并留置体外备用。结果 SD大鼠15只，10只存活且术后恢复良好，死亡原因为血管损伤、肝脏损伤、肝素过量、麻醉意外。死亡原因在操作技术熟练后可以避免。结论 大鼠肝固有动脉插管并留置体外备用的方法简单、容易掌握、成功率高，这种给药途径尤其适用于研究药物对肝脏的作用。

Establishment of a New Route in Rat for Drugs Administration

Objective To establish a route for administration of drugs to liver directly and reduce their influence on other organs. Methods A catheter was inserted in proper hepatic artery and remained one end of it outside under surgical operation microscope. Results The total number of rats in experiment was fifteen. Ten of them were alive and recovered from operation quickly. The reasons of death were vascular injury, liver damage, overdose of beparin and accident in anesthesia, which could be avoided by skilled operaters. Conclusion The above-mentioned method is simple, and easy to be mastered when drugs are given through the free end of the catheter.