多原发癌128例临床分析

目的: 探讨多原发癌(multiple primary carcinoma,MPC)的临床特点、预后及与原发癌的关系。方法: 对1993年7月~2003年6月治疗的128例MPC患者进行回顾性分析。结果: 同时性MPC41例,异时性MPC87例,双原发癌113例,三原发癌12例,四原发癌3例。先证癌发病高低顺序为头颈部、消化系统、乳腺、肺。先证癌中男性患者以头颈部、消化系统肿瘤为主,女性以乳腺、头颈部肿瘤为主。重复癌的发病高低顺序为消化系统、头颈部、肺、乳腺等。结论: 重视MPC的可能性,尤其是头颈部和消化系统肿瘤。对于诊断明确的MPC应予以根治性治疗。

Clinical analysis for 128 patients with multiple primary carcinomas

Objective: To analyze the incidence of multiple primary carcinomas.Methods: Records of 128 patients with multiple primary carcinomas during ten years period between July 1993 and June 2003 were reviewed.Results: One hundred and twenty-eight patients with multiple primary carcinomas were observed.Among them,113 patients had double primary carcinomas,12 had triple primary carcinomas,and 3 had quadruple primary carcinomas.The ratio of male to female was 2.28∶1.The average age was 58.4 years old.There were 41 synchronous carcinomas and 87 metachronous ones.The cancers in decreasing sequence were head and neck region > digestive > breast > lung.Conclusions: The possibility of multiple primary carcinomas should be emphasized,especially in head and neck cancer patients and digestive cancer patients.When diagnosis is definite,the radical therapy should be performed.