SHP-1在甲状腺癌组织中的表达及其临床意义

目的探讨甲状腺癌组织中的SHP-1蛋白表达及其意义。方法取一定量的甲状腺癌组织、癌旁组织、结节性甲状腺肿组织、正常甲状腺组织,运用PicTureTM二步法免疫组织化学染色技术检测组织中SHP-1的表达情况。结果甲状腺癌组织中的SHP-1表达阳性率为100%,明显高于其他组织(P0.05),4种病理类型的甲状腺癌组织全部表达SHP-1蛋白,且与结节性甲状腺肿组织相比较,SHP-1阳性表达的敏感度为100%,特异度为27.78%。4种甲状腺组织中,甲状腺癌SHP-1强阳性表达率为68.97%,显著高于其他各组织(P0.01)。结论 SHP-1在甲状腺癌组织中呈异常高表达,特异性差,提示SHP-1蛋白的表达增高与甲状腺癌的发生关系密切,但尚不能作为甲状腺癌的标志分子,其强阳性表达可为甲状腺癌的诊断提供参考。

Expression and Clinical Significance of SHP-1 in Thyroid Carcinoma Tissue

Objective To investigate expression and clinical significance of SLIP-1 in thyroid carcinoma tissue. Methods We collceted clinical thyroid carcinoma tissue as the research object with control of the corresponding pananeoplastie tissues, nodular goiter tissue and normal thyroid tissue. We used immunohistoehemieal techniques to detect the different expression of SLIP- 1 protein of the four kinds of tissue. Results the positive rate of expression of SHP- 1 in thyroid carcinoma was 100%. It was more than that in eorresponding pananeoplastic tissue, nodular goiter tissue and normal thyroid tissue（ P 〈 0. 05）. Four types of thyroid eareinoma tissue expressed SHP-1 all. The sensitivity of positive expression of SHP-1 was 100% and the specificity was 27.78%, when we analysed the different expression between the thyroid carcinoma group and the nodular goiter group further. At the same time, we founded that the strong positive rate of expression of SHP- 1 in thyroid carcinoma group was higher than others（ P 〈 0.01 ）. Conclusion The abnormal higher expression of SHP-1 in thyroid carcinoma tissue could be related with the incidence of thyroid carcinoma closely. Although SHP-1 protein couldn＇t be expected to become a diagnosis marker,the strong positive expression of SHP-1 may be helpful for the diagnosis of thyroid carcinoma.