Facilitation of memory retrieval by pre-test morphine and its state dependency in the step-through type passive avoidance learning test in mice |
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| Authors: | Y Shiigi H Kaneto |
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| Affiliation: | Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University, Japan. |
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| Abstract: | Amnesia produced by scopolamine and cycloheximide were reversed by morphine given 30 min before the test trial (pre-test), and pre-test morphine also facilitated the memory retrieval in the animals administered naloxone during the training trial. Similarly, pre-test scopolamine partially reversed the scopolamine-induced amnesia, but not significantly; and pre-test cycloheximide failed to reverse the cycloheximide-induced amnesia. These results suggest that the facilitation of memory retrieval by pre-test morphine might be the direct action of morphine rather than a state dependent effect. |
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