C-反应蛋白与白细胞计数联合检测在上呼吸道感染中的临床应用

目的：通过研究上呼吸道感染患者C-反应蛋白（CRP）和血常规（BR）白细胞（WBC）及其分类计数，探讨其在该类患者的表现特征，旨在指导临床更好解读及应用血常规。方法采用SPSS统计软件对2829例上呼吸道感染病例的血常规和CRP水平按照性别、年龄、季节和月份等分组方式进行回顾性分析其差异及二者的相关性。结果从2829例上呼吸道感染病例的性别方面分析，WBC和中性粒细胞（N）计数在不同性别患者中差异无统计学意义（P＞0.05），男性患者CRP水平高于女性患者（P＜0.05）；从年龄方面分析，7～12岁患者的WBC和中性粒细胞计数（N）显著高于其他年龄组（P＜0.01），0～6岁患者淋巴细胞（LYM）计数和CRP与其他年龄组差异具有统计学意义（P ＜0.01）；季节分布方面，患者的WBC计数于秋季最高，冬季最低，差异具有统计学意义（P＜0.05）；而患者N计数在冬季低于其他季节（P＜0.01），患者的LYM计数则冬春季显著低于夏秋季（P＜0.01），患者CRP水平在春季显著高于其他季节（P＜0.01）。从月份来看，患者WBC和N水平元月份最低，10月份最高（P＜0.01），患者CRP水平则于5月份最高，12月份最低，但其他月份之间差异无统计学意义（P＞0.05）。CRP与WBC、N水平呈正相关关系，与LYM呈负相关关系，不同性别、不同季节分组二者相关系数不高，以年龄分组13～18岁最低，≥75岁最高，R值为分别为0.151、0.156，0.415和0.479；月份分组4月份最高，6月份最低，R值分别为0.363、0.426，0.086和0.188。结论上呼吸道感染患者血常规有年龄、季节和月份的差异，CRP水平有性别、年龄和季节的差异，临床医生应注意辩证使用该类指标，合理用药。

Relationship of C-reactive protein combined white blood cell of blood routine test in upper respiratory tract infection patients

Objective To study on the upper respiratory tract infection patients blood C-reactive protein （CRP） and total count of white blood cells （WBC） and its differential count, in order to explore in the performance of this kind of patient characteristics, and to guide clinical doctor better interpretation and application of routine blood. Methods The results of routine blood and CRP of 2 829 cases upper respiratory tract infection on the basis of sex, age, season, month grouping were analyzed, retrospectively, while the differences and the correlation were analyzed by SPSS 17.0. Results Among the 2 829 cases with the upper respiratory tract infection of routine blood gender difference, the CRP levels in man were higher than that in women, WBC and CRP of children were higher than the other age groups. WBC test of the winter was lower than the other seasons, CRP of the spring higher than the other seasons. The correlation coefficient of CRP, WBC and NEU were positively correlated, negative correlation LYM, men and women, seasonal grouping the correlation coefficient was not obvious, the age group of 13-18 years old was the lowest, the age of 75 was the highest, R value was respectively 0.151, 0.151, 0.415 and 0.479. That April was the highest group and June minimum were, R value 0.363, 0.426, 0.086 and 0.188. Conclusions Blood routine in upper respiratory tract infection patients blood routine exist differences in age, season, month. The level of CRP had differences in different gender, ages and seasons, so clinical doctors should pay attention to the dialectical use the indicators, rational drug use.