纤维支气管镜灌洗抗真菌药治疗肺部真菌感染的疗效分析

目的探讨纤维支气管镜（FB）灌洗抗真菌药治疗肺部真菌感染（PFI）的疗效。方法选取42例患者为灌洗组,给予FB灌洗治疗;对照组患者42例,给予抗真菌治疗。结果灌洗组患者总体疗效优于对照组（U=2.7794,P〈0.01）。灌洗组患者治疗后Pa O2显著高于同期对照组（t=3.4961,P〈0.01）;灌洗组患者治疗后Pa CO2显著低于同期对照组（t=17.9784,P〈0.01）。灌洗组患者治疗后痰菌阴转率显著高于对照组（χ^2=4.8496,P〈0.01）。灌洗组发热天数、住院时间短于对照组;两组均无严重并发症。对照组病死率高于灌洗组（χ^2=3.8961,P=0.0484）。结论FB灌洗抗真菌药治疗PFI,可提高有效率,缩短病程,减少并发症。

Effect analysis of fiberoptic bronchoscopy lavaging antifungal drug for treatment of pulmonary fungus infection

Objective To study the effect of lavaging antifungal drug by fiberoptic bronchoscopy（FB） for treatment of pulmonary fungus infection（PFI）. Methods There were 42 cases collected as lavage groups and who were given FB lavage treatment. There were 42 patients collected as control group who were given antifungal therapy. Results Overall curative effect of lavage group was better than that of control group（U = 2.7794, P 〈0.01）. The level of Pa O2 after treatment in lavage group was significantly higher than that at the same period in the control group（t = 3.4961, P〈 0.01）. The level of Pa CO2 after treatment in lavage group was significantly lower than that at the same period in the control group（t = 17.9784, P 〈0.01）. Negative conversion rate of phlegm germ after treatment in lavage group rate was higher than the control group（χ^2 = 4.8496, P〈 0.01）. Fever lasting days and hospitalization time in lavage group were less than that of the control group. The two groups had no serious complications. The mortality of patients in control group was higher than that of lavage group（χ^2 = 3.8961,P = 0.0484）. Conclusion FB lavaging antifungal drug treating PFI could improve the efficiency, shorten the course of the disease, and reduce the complications.