C-反应蛋白和血清降钙素原对危重患者感染的监测价值研究

目的探讨C-反应蛋白（CRP）和血清降钙素原（PCT）对危重患者感染的监测价值。方法收集2012年10月至2013年10月本院ICU病房收治的98例危重患者,根据辅助检查结果将其分为细菌感染组（68例）和病毒感染组（30例）两组,对其PCT和CRP含量进行测定。并将细菌感染组患者随机分为观察组和对照组,每组各34例;动态监测其治疗前后PCT和CRP含量的变化情况。结果细菌感染组和病毒感染组患者的PCT平均含量分别为（3.64±0.58）μg/L和（0.37±0.35）μg/L,差异具有统计学意义（t=2.437,P〈0.05）。细菌感染组和病毒感染组患者的CRP平均含量分别为（38.27±20.55）mg/L和（37.91±20.63 mg/L）相比,差异无统计学意义（t=0.694,P〉0.05）。观察组治疗后PCT的平均含量由治疗前的（3.68±0.62）μg/L下降为（0.53±0.21）μg/L,相比于对照组由治疗前的（3.59±0.51）μg/L下降为（2.67±0.43）μg/L,下降幅度更大;观察组治疗后CRP的平均含量为（13.81±5.64）mg/L,显著低于对照组的（21.53±5.38）mg/L,差异具有统计学意义（t=5.724,P〈0.05）。结论 PCT和CRP含量的动态监测在临床应用时各有优势,二者联合应用,在对危重患者感染的诊断和治疗中具有极高的临床价值。

The value research on monitoring effect of C-reactive protein and procalcitonin for critically ill patients with infection

Objective To investigate the value of C-reactive protein（CRP） and procalcitonin（PCT） monitoring of critically ill patients infection. Methods Total of 98 critically ill patients with infection were collected from October 2012 to October 2013 in ICU ward of our hospital, Those patients were divided into bacterial infection group（68 cases） and viral infection group（30 cases） according to results of laboratory examinations. The levels of PCT and CRP were measured in the two groups, respectively. And the 68 patients with bacterial infections were randomly divided into observation group and control group, with 34 cases in each group; while the changes of PCT and CRP of the two groups were dynamic monitored before and after treatment. Results The average content of PCT in patients with bacterial infection and viral infection were（3.64 ± 0.58） μg/L and（0.37 ± 0.35） μg/L, respectively, with significant difference（t = 2.437,P〈 0.05）. The average evels of CRP in patients with bacterial infection and viral infection were（38.27 ± 20.55） mg/L and（37.91 ± 20.63） mg/L, with no significant difference（t = 0.694,P〉 0.05）. After treatment, the average content of the PCT in observation group decreased to（0.53 ± 0.21） μg/L from（3.68 ± 0.62） μg/L, while in the control group the average content of the PCT decreased to（2.67 ± 0.43） μg/L from（3.59 ± 0.51） μg/L, compared with the control group, the content of the PCT in observation group decreased significantly. After treatment, the mean content of CRP was（13.81 ± 5.64） mg/L, significantly lower than the control group that with（21.53 ± 5.38） mg/L（t = 5.724,P 〈0.05）. Conclusions Monitoring of the contents of PCT and CRP in clinical applications have their own advantages, and it has high clinical value of joint application with the two indexes both in the diagnosis and treatment of infection in patients with critically ill.