大蒜素对幽门螺杆菌阴性的慢性萎缩性胃炎患者血清表皮生长因子和胃黏膜病理、表皮生长因子受体的影响

目的观察大蒜素对幽门螺杆菌（Hp）阴性慢性萎缩性胃炎（CAG）患者血清表皮生长因子（EGF）及胃黏膜病理、表皮生长因子受体（EGFR）表达水平的影响。方法采用随机对照方法,将Hp阴性慢性萎缩性胃炎患者120例随机分为治疗组和空白对照组,其中治疗组60例患者给予大蒜素治疗,对照组60例患者给予与大蒜素剂型相同的安慰剂;疗程为24周,治疗前后两组患者均进行血清EGF、胃黏膜EGFR表达以及病理积分比较。结果治疗组患者大蒜素治疗后EGF、EGFR表达水平以及病理积分较治疗前降低,差异有统计学意义（P均〈0.05）;对照组患者治疗前后EGF、EGFR表达水平以及病理积分差异无统计学意义（P均〉0.05）。结论大蒜素对慢性萎缩性胃炎的病理积分有改善作用,且能够降低萎缩性胃炎EGF及EGFR的表达水平,这可能是其发挥作用的机制之一。

Influences of allicin on serum epidermal growth factor,gastric mucosa epidermal growth factor receptor expression and pathological points of chronic atrophic gastritis without Helicobacter pylori infection

Objective To explore the influences of allicin on serum epidermal growth factor（EGF）, gastric mucosa epidermal growth factor receptor（EGFR） expression and pathological points of chronic atrophic gastritis（CAG） without Helicobacter pylori（Hp） infection. Methods Total of 120 patients with Hp negative CAG diagnosed by the gastroscopy and pathological examination were investigated by randomized control method in Qingdao Municipal Hospital. They all were randomly divided into treatment group and control group, with 60 cases in each group. Patients in treatment group were given allicin while patients in control group were given placebo. The period of treatment for the two groups were 24 weeks. The findings of gastroscopy and histology of gastric mucosa, as well as the serum EGF and gastritis mucosa EGFR were recorded and compared before and after the treatment, respectively. Results After therapy, EGF, EGFR expression and pathological points were lower than before in treatment group, with significant differences（P all 〈0.05）; while that in the control group was not with significant difference（P all 〉0.05）. Conclusions Allicin could improve chronic atrophic gastritis pathological points and significantly improve the pathological situation, and reduce the levels of serum EGF and gastric mucosa EGFR expression, which may be one of the mechanisms of allicin improving pathological points for the Hp-negative CAG.