| 中耳胆脂瘤上皮的PCNA和Bcl-2检测及临床意义 |
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| 引用本文： | 潘宏光,崔永华,高起学.中耳胆脂瘤上皮的PCNA和Bcl-2检测及临床意义[J].华中科技大学学报(医学版),2001,30(2):163-164. |
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| 作者姓名： | 潘宏光 崔永华 高起学 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院耳鼻咽喉科, |
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| 摘 要： | 应用免疫组织化学方法检测25例胆脂瘤上皮和10例耳后皮肤的增殖细胞核抗原(proliferatingcellnuclearantigen,PCNA)和B-celllymphoma/leukemia-2gene(Bcl-2)的表达情况,结果发现胆脂瘤上皮的PCNA指数明显高于正常皮肤,且胆脂瘤上皮的PCNA指数与其破坏能力有相关性;而Bcl-2无表达.提示①PCNA可作为评价胆脂瘤破坏力的一指标;②胆脂瘤虽然表现出很强的增殖能力,但没有促其恶变的趋势.
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| 关 键 词： | 胆脂瘤 中耳炎 增殖细胞核抗原 bcl-2基因 免疫组织化学 |
| 修稿时间： | 1999年11月4日 |
Expression of
Proliferating Cell Nuclear Antigen and B-cell Lymphoma/Leukemia-2 Gene in Cholesteatoma
and Its Clinical Implication |
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| Pan Hongguang,Cui Yonghua,GAO Qixue.Expression of
Proliferating Cell Nuclear Antigen and B-cell Lymphoma/Leukemia-2 Gene in Cholesteatoma
and Its Clinical Implication[J].Journal of Huazhong University of Science and Technology(Health Sciences),2001,30(2):163-164. |
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| Authors: | Pan Hongguang Cui Yonghua GAO Qixue |
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| Institution: | Pan Hongguang,Cui Yonghua,Gao Qixue Department of Otolaryngology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | The expression of proliferating cell nuclear antigen (PCNA) and B cell lymphoma/leukemia 2 gene (Bcl 2) was detected in 25 cases of cholesteatoma tissues and 10 cases of normal skin by using immunohistochemical technique The results showed that the PCNA index of cholesteatoma tissues was higher than that of normal skin, but Bcl 2 was not expressed in cholesteatoma tissues and normal skin The PCNA index was correlated with the aggressiveness of cholesteatoma It was suggested that PCNA could be considered to be a prognostic marker and an indicator of aggressive behavior in cholesteatoma Although the cholesteatoma had a very high proliferating character, it wasn't a malignant tumor |
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| Keywords: | cholesteatoma otitis PCNA Bcl 2 gene imunohistochemistry |
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