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乙型肝炎患者凝血功能与临床分型及血清HBV—DNA定量检测关系的研究
引用本文:邹宇,王丽华,邓小玲.乙型肝炎患者凝血功能与临床分型及血清HBV—DNA定量检测关系的研究[J].检验医学与临床,2009,6(3):167-170.
作者姓名:邹宇  王丽华  邓小玲
作者单位:重庆市江津区人民医院,402260
摘    要:目的研究乙型肝炎(下称乙肝)患者凝血功能与乙肝临床分型及血清乙肝病毒核糖核酸(HBV—DNA)定量检测之间的关系。方法收集乙肝患者330例为研究组,收集健康人群50例作为健康对照组,分别检测凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、纤维蛋白原(FIB)等凝血功能指标及血清HBV-DNA含量,比较临床分型各组的PT、APTT、FIB的关系和按血清的HBV—DNA定量分组的各组PT、APTT、FIB的关系。结果除了慢性乙肝(轻度)组的PT值与健康对照组差异无统计学意义外,其他各组乙肝患者的PT、APTT值都与健康对照组差异有统计学意义(P〈0.05),特别是慢性乙肝(重度)和乙肝后肝硬化组与健康对照组、慢性乙肝(轻度)组相比3项值差异有统计学意义(P〈0.01)。按血清HBV—DNA定量分组的各组患者的PT、APTT值与健康对照组相比差异有统计学意义(P〈0.05),且DNA定量大于或等于10^3copy/mL的各组患者的APTT值都显著高于健康对照组(P〈0.01)。结论慢性乙肝患者凝血功能异常程度随临床分型的加重而加重,但与病毒拷贝数的增加无正相关。APTT值的检测是反映乙肝患者凝血功能的灵敏指标。

关 键 词:乙型肝炎  凝血功能  临床分型  乙肝病毒核糖核酸

The study of the relationships between blood coagulation function and the clinical grading of hepatitis B as well as serum content of HBV-DNA
ZOU Yu,WANG Li-hua,DENG Xiao-ling.The study of the relationships between blood coagulation function and the clinical grading of hepatitis B as well as serum content of HBV-DNA[J].Laboratory Medicine and Clinic,2009,6(3):167-170.
Authors:ZOU Yu  WANG Li-hua  DENG Xiao-ling
Institution:ZOU Yu,WANG Li-hua,DENG Xiao-ling.The People's Hospital of Jiangjin Distict,Chongqing 402260,China
Abstract:Objective To study the relationships between blood coagulation function and the clinical grading of hepatitis B as well as serum content of HBV-DNA in patients with hepatitis B.Methods Three hundred and thirty cases of patients with hepatitis B and fifty healthy individuals(healthy control group) were enrolled in the study.The blood coagulation function indicators(prothrombin time,PT;activated partial thromboplastin time,APTT;fibrinogen,FIB) and the content of HBV-DNA in the sera of the patients with hepati...
Keywords:hepatitis B  blood coagulation function  clinical grading  HBV-DNA  
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