乳腺癌超声弹性成像与TLR9、Her-2和ER的相关性

目的探讨乳腺癌的常规超声结合超声弹性成像的特征与Toll样受体9(Toll-Like Receptor 9,TLR9)、人表皮生长因子受体-2(Human epidermal growth factor receptor-2,Her-2)和雌激素受体(Estrogen Receptor,ER)的相关性。方法收集牡丹江医学院附属红旗医院门诊或者住院于2017年1月至2018年12月收治的乳腺癌患者176例。于手术或病理活检前行常规超声及超声弹性成像检查,并进行评分。采用免疫组织化学染色检测TLR9、Her-2和ER的阳性表达。分析超声征象与TLR9、Her-2和ER表达的相关性。结果肿瘤大小、形状、微小钙化、血供、淋巴转移、弹性评分与TLR9相关(P<0.05);肿瘤形状、边缘、微小钙化、血供、淋巴转移与Her-2相关(P<0.05);肿瘤形状、边缘、淋巴转移与ER相关(P<0.05)。结论乳腺癌超声特征与TLR9、Her-2、ER阳性表达有一定的相关性,联合检测可提高乳腺癌诊断的准确性。

Correlation between the Ultrasound Elastography of Breast Cancer and TLR9,Her-2 and ER

Objective To investigate the correlation between the fetures of conventional ultrasound combined with ultrasound elastography in breast cancer and Toll-Like Receptor 9(TLR9),Human epidermal growth factor receptor-2(Her-2),Estrogen Receptor(ER).Methods A total of 176 patients with breast cancer of the Affiliated Hongqi Hospital of Mudanjiang Medical University admitted from January 2017 to December 2018 were evaluated.Conventional ultrasound and ultrasound elastography were performed before surgery or pathological biopsy and scored.The positive expressions of TLR9,Her-2 and ER were detected by immunohistochemical staining.The correlation between ultrasound signs and the expressions of TLR9,Her-2 and ER was analyzed.Results Tumor size,shape,microcalcification,blood supply,lymphatic metastasis,and elastic score were correlated with TLR9(P<0.05);Tumor shape,margin,microcalcification,blood supply,lymphatic metastasis were correlated with Her-2(P<0.05);Shape,margin,lymphatic metastasis and ER(P<0.05).Conclusion The ultrasound characteristics of breast cancer have a certain correlation with the positive expression of TLR9,Her-2 and ER.Combined detection can improve the accuracy of breast cancer diagnosis.